Evidence of a Prolonged Post‐Mental Stress Decline in Flow‐Mediated Dilation in Young Healthy Subjects
Bibliographic record
Abstract
A temporary depression in reactive hyperemia stimulated flow‐mediated dilation (RH‐FMD) has been observed in young healthy individuals after an acute bout of mental stress. While it has been shown that a post‐stress reduction in RH‐FMD persists for 90 minutes in middle‐aged participants, it is unclear whether the impairment is similarly prolonged in a young healthy population. The objective of this pilot study was therefore to examine brachial artery RH‐FMD at 90 minutes post‐acute mental stress in young healthy volunteers. Doppler and echo ultrasound were used to obtain brachial artery diameter and velocity respectively. The shear stress stimulus was characterized as the shear rate (SR = velocity/diameter) area under the curve (SR‐AUC) during the first 30 seconds following forearm cuff deflation. Data are mean ± SD. Four men and two women aged 22.2 ± 3.7 years participated. RH‐FMD was assessed at baseline and 90 minutes following a stress task based on the Trier Social Stress Test (TSST). The average subjective stress rating for the TSST was 6.7 ± 1.8 (on a subjective scale of 1‐10). SR‐AUC was not significantly different at baseline (2304.9 ± 1055.2) compared to 90 minutes post‐mental stress (3022.9 ± 1224.7; P = 0.171). RH‐FMD was significantly lower in participants at 90 minutes post‐stress (6.7 ± 5.5%) compared to baseline (9.3 ± 3.7%; P = 0.025). These preliminary findings suggest that acute mental stress can have a prolonged (90 minute) detrimental effect on endothelial function in young healthy adults. Funded by NSERC and CFI.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".