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Record W2969471187 · doi:10.1101/19004622

Atypical somatic symptoms in adults with prolonged recovery from mild traumatic brain injury

2019· preprint· en· W2969471187 on OpenAlexafffund
Jacob L. Stubbs, Katherine E. Green, Noah D. Silverberg, Andrew Howard, Amrit K. Dhariwal, Jeffrey R. Brubacher, Naisan Garraway, Manraj K.S. Heran, Mypinder S. Sekhon, Angela Aquino, Victoria Purcell, James S. Hutchison, Ivan J. Torres, William J. Panenka

Bibliographic record

VenuemedRxiv · 2019
Typepreprint
Languageen
FieldMedicine
TopicTraumatic Brain Injury Research
Canadian institutionsMental Health Research CanadaSickKids FoundationUniversity of TorontoVancouver General HospitalVancouver Coastal HealthVancouver Coastal Health Research InstituteBC Mental Health & Substance Use ServicesHospital for Sick ChildrenUniversity of British Columbia
FundersGenome British ColumbiaFondation Brain Canada
KeywordsRivermead post-concussion symptoms questionnaireTraumatic brain injuryMedicineConcussionSomatizationPost-concussion syndromeYoung adultInternal medicinePhysical therapyPsychiatryPoison controlInjury preventionAnxiety

Abstract

fetched live from OpenAlex

ABSTRACT Somatization may contribute to persistent symptoms after mild traumatic brain injury (mTBI). In two independently-recruited study samples, we characterized the extent to which symptoms atypical of mTBI but typical for somatoform disorders (e.g., gastrointestinal upset, joint pain) were present in adult patients with prolonged recovery following mTBI. The first sample was cross-sectional and consisted of mTBI patients recruited from the community who reported ongoing symptoms attributable to a previous mTBI ( n = 16) along with a healthy control group ( n = 15). The second sample consisted of patients with mTBI prospectively recruited from a Level 1 trauma center who had either good recovery (GOSE = 8; n = 33) or poor recovery (GOSE < 8; n = 29). In all participants, we evaluated atypical somatic symptoms using the Patient Health Questionnaire-15 and typical post-concussion symptoms with the Rivermead Post-Concussion Symptom Questionnaire. Participants with poor recovery from mTBI had significantly higher ‘atypical’ somatic symptoms as compared to the healthy control group in Sample 1 ( b = 4.308, p = 9.43E -5 ) and to mTBI patients with good recovery in Sample 2 ( b = 3.287, p = 6.83E -04 ). As would be expected, participants with poor outcome in Sample 2 had a higher burden of typical rather than atypical symptoms ( t (28) = 3.675, p = 9.97E -04 , d = 0.94). However, participants with poor recovery still reported atypical somatic symptoms that were significantly higher (1.4 standard deviations, on average) than those with good recovery. Our results suggest that although ‘typical’ post-concussion symptoms predominate after mTBI, a broad range of somatic symptoms also frequently accompanies mTBI, and that somatization may represent an important, modifiable factor in mTBI recovery.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.052
GPT teacher head0.325
Teacher spread0.273 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2019
Admission routes2
Has abstractyes

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