Influence of serum estradiol on serum uric acid level in pre and postmenopausal women.
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Case-control clinical study of estradiol and uric acid levels.
The study examines estradiol and uric acid levels in menopausal women.
Clinical association of estradiol and uric acid in women; biomedical physiology.
Abstract
Background: Hyperuricemia develops when serum uric acid level exceeds the normal value. Estrogen may influence the level of serum uric acid. Postmenopausal females have a remarkable reduction in its level, so serum estradiol is studied in relation to serum uric acid levels in pre and post-menopausal women. Objective: To find out the relationship of serum Estradiol with serum uric acid level in premenopausal and postmenopausal women in local population. Study Design: Case control study. Setting: This study was conducted in Lady Aitchison Hospital Lahore. Period: March 2017- August 2017. Material and Methods: 134 females were enrolled in total and were grouped in to two. Group A comprised of premenopausal and Group B included postmenopausal females. After complete history and general physical examination, 5 ml venous blood sample under aseptic measures was taken. Serum uric acid was measured by enzymatic and serum estradiol by Enzyme-linked immunosorbent assay method. Results: The mean age of pre and postmenopausal women was 32 and 57 ± 7 years, with significantly lower in premenopause. The mean serum E2 was 91.86 ± 26.71 mg/dL in premenopause and 22.04 ± 9.28 mg/dL in postmenopause, with significantly lower mean in postmenopause. Mean serum uric acid was statistically higher in postmenopause that was 6.04 ± 0.58 mg/dL, when compared to premenopause that was 4.22 ± 0.90 mg/dL. Conclusion: Serum uric acid levels increased due to decreased serum estradiol in postmenopausal women as compared to premenopausal women.
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The record
- Venue
- The Professional Medical Journal
- Topic
- Gout, Hyperuricemia, Uric Acid
- Field
- Medicine
- Canadian institutions
- Continental (Canada)
- Funders
- —
- Keywords
- MedicineUric acidInternal medicineHyperuricemiaEndocrinologyPostmenopausal womenEstrogenMenopauseVenous blood
- Has abstract in OpenAlex
- yes