Оптимизация назначения антиангинальных препаратов: рандомизированное, сравнительное изучение изосорбида‑5‑мононитрата продленного действия в сравнении с изосорбида динитратом у больных ишемической болезнью сердца со стабильной стенокардией напряжения
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Aim. To compare effectiveness and tolerability of a regular treatment with two nitrates – moderately long-acting isosorbide dinitrate and very long-acting isosorbide-5-mononitrate – in patients with coronary heart disease (CHD) and stable effort angina. Material and methods. The study included 30 patients with verified CHD: 4 females, 26 males; mean age 50.5 years. In total, 21 participants had myocardial infarction (MI) in anamnesis, including 3 with recurrent MI. At coronaroangiography, 6 individuals had coronary stenosis of ≥75%, in at least one artery. Mean duration of stable angina was 8.2 years; 21 patients had functional class (FC) II angina, and 9 – FC III angina, by Canadian Cardiology Association’s classification. Pharmacodynamics was studied in placebo, isosorbide-5-mononitrate, and isosorbide dinitrate treatment regimens. Antianginal and antiischemic effects were assessed by increased physical stress (PS) tolerance – increased time before moderately intensive angina episode, by at least 120 s, comparing to placebo. Each drug was administered for 4 weeks, control period between the courses lasted for 7 days. Results. All patients regularly received individually selected doses of antianginal medications. The therapy was associated with statistically significant increase in all PS tolerance parameters, measured one hour after medication’s intake, comparing to placebo. Isosorbide-5-mononitrate and isosorbide dinitrate treatment was associated with 14 and 18 adverse events, respectively. Conclusion. In CHD patients with FC II-III stable effort angina, isosorbide-5-mononitrate therapy (in an individual dose, once per day) demonstrated a clear, sustained antianginal effect, was well-tolerated, and did not cause clinically manifested tolerance.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.006 | 0.008 |
| Meta-epidemiology (narrow) | 0.009 | 0.010 |
| Meta-epidemiology (broad) | 0.011 | 0.007 |
| Bibliometrics | 0.004 | 0.007 |
| Science and technology studies | 0.004 | 0.005 |
| Scholarly communication | 0.003 | 0.004 |
| Open science | 0.006 | 0.004 |
| Research integrity | 0.006 | 0.012 |
| Insufficient payload (model declined to judge) | 0.014 | 0.039 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it