The influence of LPS and zinc on interaction between mother and offspring
Bibliographic record
Abstract
Introduction The maternal behavior consists of a set of behavioral and physiological changes in adults, performed around the reproductively immature individuals, ensuring their survival and propagation of the species. Offsprings give signal to be collected when separated from their mother through olfactory, visual and sound signals. Infection and its influence in the context of the interaction between mother and offspring is poorly investigated. The classic disease model, which is widely used, involves the treatment with lipopolysaccharide (LPS), the major component of the cell wall of Gram‐negative bacteria. The infections can activate a chain of nonspecific host responses, including the immune response and levels of zinc. Objective To investigate the behavioral and neuroimmunological adaptations of rats and their offspring resulting from experimental inflammation produced by LPS and the possible influence of zinc treatment on these adaptations. Methods In this study, virgin, pregnant and lactating female rats received LPS (100 μg/kg, ip) and then were treated with zinc (2 mg/kg, sc). Temperature, body weight, water and food consumption were measured for ninety‐six hours, starting two hours after LPS administration. On the fifth day of lactation, maternal behavior, the overall activity in the open field and ultrasonic vocalization in offsprings were observed. On the day of weaning, pups of these females received a challenge with LPS (50 μg/kg, ip) and two hours after administration were observed for general activity in the open field. The burst and phagocytosis of leukocytes in the blood of pups was also studied. Results 1) in virgin, pregnant and lactating rats, the exposure to LPS and the treatment with zinc modified the temperature, body weight, water and food consumption, and the general activity observed in the open field. Virgin, pregnant or lactating rats responded differently to this treatment. 2) In the lactation period the latency to search the first pup was reduced. 3) In the offspring, a change in the pattern of vocalization of the offspring, changes in general activity observed in the open field and changes in the burst and phagocytosis of leukocytes on the twenty‐first day of lactation after challenge with endotoxin were detected. Conclusion the results indicate that administration of LPS and treatment with zinc have effects modulated according to the physiological stage of the female. These effects interfere with the interaction between a mother and her offspring, resulting in short and long term effects in offspring's behavior. Exposure of mothers to bacterial endotoxin modulates the effects caused by zinc and programs the inflammatory responses in the offspring. Support or Funding Information Coordination for the Improvement of Higher Education Personnel (CAPES) Natural Sciences and Engineering Research Council (NSERC) Canadian Centre for Health and Safety in Agriculture (CCHSA) This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".