Effects of oral gabapentin, tramadol and meloxicam on ocular parameters in healthy dogs
Bibliographic record
Abstract
The objectives of this study were to determine the effects of oral gabapentin, tramadol and meloxicam on ocular parameters when given to healthy dogs for three days. Nine, healthy, intact male Beagles were utilized for a randomized, blinded, case-crossover study using a 6-sequence, 3-treatment, 3-period design, including a 7-day acclimation period, three, 3-day treatment periods followed by a 7-day washout period. Dogs received gabapentin (10mg/kg PO q8hr), tramadol (3mg/kg PO q8hr), and meloxicam (0.2mg/kg PO once, then 0.1mg/kg PO q24). Ocular parameters were evaluated several times per day. Comparing acclimation period measurements from days 1-5 and 6-7 confirmed that a 5-day acclimation period is required for intraocular pressure values to return to baseline in canine patients (p-value = 0.0021). When accounting for repeat measures within individuals, gabapentin and tramadol significantly affected only IOP (-0.45 and -0.35mmHg, respectively; p-value = 0.038). Although statistically significant, this reduction is not considered clinically significant.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".