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Record W2975915192 · doi:10.14740/jmc3362

A Patient With Sporotrichosis Diagnosed By Molecular Biology Combined With Traditional Methods

2019· article· en· W2975915192 on OpenAlexvenueno aff
Runchao Wang, Haixia Jing, Chen Shaoxiu, Yao Yang, Hualiang Nan, Tingting Chen

Bibliographic record

VenueJournal of Medical Cases · 2019
Typearticle
Languageen
FieldMedicine
TopicFungal Infections and Studies
Canadian institutionsnot available
Fundersnot available
KeywordsSporotrichosisSporothrix schenckiiGenBankMedicinePathologyDNA extractionFungal pathogenDermatologyBiologyMicrobiologyPolymerase chain reactionPathogenImmunologyGeneticsGene

Abstract

fetched live from OpenAlex

We present a case of sporotrichosis diagnosed by molecular biology combined with traditional methods. Fungal DNA was extracted from skin tissues of the patient by fungal DNA extraction kit. The PCR amplified fragments were compared on GenBank website, and the pathogenic fungi were identified. This case was diagnosed by molecular biology, clinical manifestations, fungal morphology and pathology. The pathogenic fungi of the patient was identified as Sporothrix globosa by comparison, combined with typical clinical manifestations, typical filamentous colonies by fungi culture and pathological findings of infectious granuloma. The case could be diagnosed as Sporothrix globosa -induced sporotrichosis. Molecular biology combined with traditional detection methods for diagnosis of sporotrichosis is helpful to improve the accuracy of diagnosis. J Med Cases. 2019;10(9):284-287 doi: https://doi.org/10.14740/jmc3362

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.412
Threshold uncertainty score0.867

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.024
GPT teacher head0.332
Teacher spread0.308 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2019
Admission routes1
Has abstractyes

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