Automatic Classification and Monitoring of Denovo Parkinson’s Disease by Learning Demographic and Clinical Features
Bibliographic record
Abstract
Parkinson's Disease (PD) is the second most prevalent progressive neurological disorder around the world with high incidence rates for seniors. Since most symptoms are exposed in the later stages of the disease, early diagnosis of PD is essential for more effective treatment. The motivation of this research is early automatic assessment of PD using clinical information, not only for disease diagnosis but also for monitoring progression. After preprocessing the data, feature selection is done by the Mean Decrease Impurity (MDI) method. In the classification step, Random Forest (RF) is used as a classifier model for two tasks, including (1) classifying the subjects to PD and Healthy Control (HC), and (2) determining the disease severity level by Hoehn & Yahr (H&Y) scale. The clinical data used is taken from the Parkinson's Progression Markers Initiative (PPMI) database, which is the most prominent source of data for PD. Experimental results show promising performance of the proposed model for assessment of PD by incorporating clinical properties.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".