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Record W2980663762 · doi:10.1038/s41586-019-1775-1

Longitudinal molecular trajectories of diffuse glioma in adults

2019· article· it· W2980663762 on OpenAlexaff
Floris P Barthel, Kevin C. Johnson, Frederick S. Varn, Anzhela D. Moskalik, Georgette Tanner, Emre Kocakavuk, Kevin Anderson, Olajide Abiola, Kristin Alfaro-Munoz, Donát Alpár, Samirkumar B. Amin, David M. Ashley, Pratiti Bandopadhayay, Jill S. Barnholtz‐Sloan, Rameen Beroukhim, Christoph Bock, Priscilla K. Brastianos, Daniel J. Brat, Andrew Brodbelt, Alexander Bruns, Arnab Chakravarti, Jeffrey H. Chuang, Elizabeth B. Claus, Jennifer Connelly, J Costello, Gaetano Finocchiaro, Michael Fletcher, Pim J. French, Mark R. Gilbert, Peter V. Gould, Matthew Grimmer, Antonio Iavarone, Azzam Ismail, Michael D. Jenkinson, Mustafa Khasraw, Hoon Kim, Peter S. LaViolette, Tathiane M. Malta, Tali Mazor, Kerrie L. McDonald, Annette M. Molinaro, Naema Nayyar, Ho‐Keung Ng, Chew Yee Ngan, Simone P. Niclou, Johanna M. Niers, Houtan Noushmehr, Javad Noorbakhsh, Chul‐Kee Park, Laila Poisson, Raúl Rabadán, Bernhard Radlwimmer, Guido Reifenberger, K. Jason, Michael Schuster, Brian Shaw, Susan Short, Peter A. Sillevis Smitt, Andrew E. Sloan, Marion Smits, Ghazaleh Tabatabai, Colin Watts, Michael Weller, Pieter Wesseling, Bart A. Westerman, Georg Widhalm, W. K. Alfred Yung, Gelareh Zadeh, John de Groot, Lucy F. Stead, Roel G.W. Verhaak, W.K. Alfred Yung

Bibliographic record

VenueNature · 2019
Typearticle
Languageit
FieldMedicine
TopicGlioma Diagnosis and Treatment
Canadian institutionsUniversity Health NetworkHospital for Sick ChildrenUniversité LavalHôpital de l'Enfant-Jésus
FundersNational Institute of General Medical SciencesNational Cancer InstituteNational Center for Advancing Translational SciencesNational Institute of Neurological Disorders and StrokeBrain Tumour Charity
KeywordsGliomaBiologySomatic hypermutationSomatic evolution in cancerCancer researchGeneAneuploidyPhenotypeCell cycleGeneticsChromosome

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.029
Threshold uncertainty score0.057

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.252
Teacher spread0.246 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations595
Published2019
Admission routes1
Has abstractno

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