P2‐428: MYELOPROLIFERATIVE CONDITIONS IN OLDER ADULTS WITH MAJOR NEUROCOGNITIVE DISORDERS: IS THERE AN ASSOCIATION?
Bibliographic record
Abstract
Myeloproliferative disorders (MPD) are heterogeneous conditions associated with a proliferation of blood counts. Polycythemia rubra vera (PV), essential thrombocytosis/thrombocythemia (EV) and primary or idiopathic myelofibrosis are clonal disorders with similar genetic and clinical features. Major neurocognitive disorders, otherwise referred to as dementias are common in advancing age groups. Patients with neurocognitive disorders have heterogenous profiles. Reviewing medical histories and laboratory investigations and the exclusion of potentially reversible metabolic, electrolyte and other medical conditions are imperative in diagnosing and managing neurocognitive disorders. We report on 11 patients seen in the outpatient clinic setting for cognitive evaluation against the backdrop of suspected dementias. None of these patients had been diagnosed with a myeloproliferative disorder or other major hematological condition prior to the assessment. Patients with neurocognitive disorders have heterogeneous profiles. Reviewing medical histories and laboratory investigations are perquisites to making dementia diagnosis. The baseline characteristics of the patients revealed male predominance (n = 9; 81.82%), College or university education (n=5; 45.45%) JAK 2 v617 mutation analysis was undertaken. This was present in 7 patients. Clinical features of vascular and Alzheimer's dementia were identified in all the patients. One of the patients had persistent perceptual disturbances which led to a suspicion that he had Lewy body dementia. The prominent cognitive domains were with working memory (100%), visuospatial deficits (81.82%) and executive function (100%). Other cognitive deficits reported were inattention, disorientation and language (anomia and poor semantic and verbal fluencies). Functional and cognitive improvements following the diagnosis and management of these myeloproliferative conditions. Hydroxyurea (HU) was initiated in 8 patients with essential thrombocytosis and polycythemia rubra vera. Subjective and objective improvements in cognition and behaviors occurred in 4 patients who commenced HU. Three patients did not initiate HU therapy and 1 patient discontinued HU after 3 months of therapy. Our observation highlights the importance of identifying potentially reversible etiologies for cognitive impairment. Terms: Neurocognitive disorders, dementia(s), myeloproliferative disorders.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.007 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".