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Record W2981275313 · doi:10.1038/s41591-019-0613-1

Pan-viral serology implicates enteroviruses in acute flaccid myelitis

2019· article· en· W2981275313 on OpenAlexaff
Ryan Schubert, Isobel A. Hawes, Prashanth Ramachandran, Akshaya Ramesh, Emily Crawford, John E. Pak, Wesley Wu, Carly K. Cheung, Brian D. O’Donovan, Cristina M. Tato, Amy Lyden, Michelle Tan, Rene Sit, Gavin M. Sowa, Hannah A. Sample, Kelsey C. Zorn, Debarko Banerji, Lillian M. Khan, Riley Bove, Stephen L. Hauser, Amy A. Gelfand, Bethany Johnson-Kerner, Kendall Nash, Kalpathy S. Krishnamoorthy, Tanuja Chitnis, Joy Zhuo Ding, Hugh J. McMillan, Charles Y. Chiu, Benjamin Briggs, Carol Glaser, Cynthia Yen, Victoria Chu, Debra A. Wadford, Samuel R. Dominguez, Terry Fei Fan Ng, Rachel L. Marine, Adriana Lopez, W. Allan Nix, Ariane Soldatos, Mark Gorman, Lina Benson, Kevin Messacar, Jennifer L. Konopka‐Anstadt, M. Steven Oberste, Joseph L. DeRisi, Michael R. Wilson

Bibliographic record

VenueNature Medicine · 2019
Typearticle
Languageen
FieldMedicine
TopicViral Infections and Immunology Research
Canadian institutionsChildren's Hospital of Eastern OntarioUniversity of Ottawa
FundersNational Institute of Allergy and Infectious DiseasesCenters for Disease Control and PreventionMultiple Sclerosis SocietyUniversity of California, San FranciscoAmerican Brain FoundationNational Institute of Neurological Disorders and StrokeCalifornia Department of Public HealthNational Multiple Sclerosis SocietyAmerican Academy of NeurologyNational Institutes of HealthU.S. Department of Health and Human Services
KeywordsEnterovirusSerologyVirologyAntibodyPicornaviridaeMyelitisRNAEtiologyVirusEpitopeCerebrospinal fluidBiologyImmunologyMedicinePathologySpinal cordGeneticsGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.252
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.009
GPT teacher head0.340
Teacher spread0.331 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations132
Published2019
Admission routes1
Has abstractno

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