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Record W2981836228 · doi:10.1080/10715762.2019.1677902

Visualising reactive oxygen species in live mammals and revealing of ROS-related system

2019· article· en· W2981836228 on OpenAlexfundno aff
Jingke Guo, Hang Xu, Liu S, You Dai, Jianzhi Lu, Dazheng Xu, Jianwu Zhou, Lijing Ke, Xi Cheng, Mingming Xu, Xin Zhang, Yi Guo, Yingjie Lin, Wei Ding, Guanzhen Gao, Huiqin Wang, Qi Chen, Xiaowei Yu, Han Chen, Lina Qin, Xicui Sun, Zhe Li, Shuyu Zheng, Jiaqi Wang, Yanglei Cheng, Shuai Qiu, Yuqiu Hu, Penghan Huang, Chuntong Lin, Qiming Wu, Yubo Li, Tianbao Chen, Chris Shaw, Sherry Ho, Qiang Wang, Huaiyu Gu, Pingfan Rao

Bibliographic record

VenueFree Radical Research · 2019
Typearticle
Languageen
FieldNeuroscience
TopicNeuroscience of respiration and sleep
Canadian institutionsnot available
FundersNatural Science Foundation of Zhejiang ProvinceQueen's UniversityNational Natural Science Foundation of ChinaQuanzhou Normal UniversityQueen's University Belfast
KeywordsReactive oxygen speciesConnective tissueMitochondrionAnatomySuperoxideChemistryCell biologyBiophysicsBiologyBiochemistryGenetics

Abstract

fetched live from OpenAlex

Of all the aerobic respiration by-products, cytotoxic superoxide derived from mitochondrial-leaked electrons, is the only one known to be disposed of intracellularly. Is this fate the only destiny for mitochondrial-leaked electrons? When Cynomolgus monkeys were injected intravenously with reactive oxygen species (ROS) indicators, the connective tissues of dura mater, facial fascia, pericardium, linea alba, dorsa fascia and other body parts, emitted specific and intense fluorescent signals. Moreover, the fluorescent signals along the linea alba of SD rats, did not result from the local presence of ROS but from the interaction of ROS indicators with electrons flowing through this tissue. Furthermore, the electrons travelling along the linea alba of mice were revealed to originate from mitochondria. These data suggest that mitochondrial-leaked electrons may be transported extracellularly to a hitherto undescribed system of connective tissues, which is pervasively networked, electrically conductive and metabolically related.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.007

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.101
GPT teacher head0.371
Teacher spread0.271 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2019
Admission routes1
Has abstractyes

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Same venueFree Radical ResearchSame topicNeuroscience of respiration and sleepFrench-language works237,207