Anti-inflammatory role of chromofungin, a chromogranin A-derived peptide, in the context of colitis
Bibliographic record
Abstract
Ulcerative colitis(UC) is characterized by a decreased level of chromofungin (CHR: Chormogranin-A 47-66) and a dysregulation of CD11c+ cells. We aimed to investigate the association between CHR and CD11c+ cells in an experimental model of UC. Colitis was induced in C57BL/6 mice by 5% dextran sulfate sodium with intra-rectal injection of CHR. Disease activity was monitored and colonic, mesenteric lymph node and splenic levels of pro-inflammatory cytokines and CD markers were assessed using ELISA and/or RT-qPCR. In-vivo, CHR treatment reduced colitis with a significant decrease in colonic levels of pro-inflammatory markers. In MLN, CHR decreased CD11c+ markers and in splenic CD11c+ cells CHR decreased CD40 and CD80. RT-2 PCR array demonstrated a downregulation of NF-kB in colon and in CD11c+ isolated cells from mice treated with CHR. NF-kB blocker/activator studies confirmed regulation by CHR. CHR regulates the development of colitis through the modulation of CD11c+ cells markers of immune activation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".