Anti-inflammatory role of chromofungin, a chromogranin A-derived peptide, in the context of colitis
Bibliographic record
Abstract
Ulcerative colitis(UC) is characterized by a decreased level of chromofungin (CHR: Chormogranin-A 47-66) and a dysregulation of CD11c+ cells. We aimed to investigate the association between CHR and CD11c+ cells in an experimental model of UC. Colitis was induced in C57BL/6 mice by 5% dextran sulfate sodium with intra-rectal injection of CHR. Disease activity was monitored and colonic, mesenteric lymph node and splenic levels of pro-inflammatory cytokines and CD markers were assessed using ELISA and/or RT-qPCR. In-vivo, CHR treatment reduced colitis with a significant decrease in colonic levels of pro-inflammatory markers. In MLN, CHR decreased CD11c+ markers and in splenic CD11c+ cells CHR decreased CD40 and CD80. RT-2 PCR array demonstrated a downregulation of NF-kB in colon and in CD11c+ isolated cells from mice treated with CHR. NF-kB blocker/activator studies confirmed regulation by CHR. CHR regulates the development of colitis through the modulation of CD11c+ cells markers of immune activation.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".