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Record W2982514207 · doi:10.1126/scisignal.aax1194

iRhom2 inhibits bile duct obstruction–induced liver fibrosis

2019· article· en· W2982514207 on OpenAlex
Balamurugan Sundaram, Kristina Behnke, Andrea Belancic, Mazin A. Al-Salihi, Yasser Thabet, Robin Polz, Rossella Pellegrino, Yuan Zhuang, Prashant V. Shinde, Haifeng C. Xu, Jeļena Vasiļevska, Thomas Longerich, Diran Herebıan, Ertan Mayatepek, Hans H. Bock, Petra May, Claus Kordes, Nima Aghaeepour, Tak W. Mak, Verena Keitel, Dieter Häussinger, Jürgen Scheller, Aleksandra A. Pandyra, Karl S. Lang, Philipp A. Lang

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueScience Signaling · 2019
Typearticle
Languageen
FieldMedicine
TopicLiver Disease Diagnosis and Treatment
Canadian institutionsCanada Research Chairs
Fundersnot available
KeywordsBile ductLiver fibrosisFibrosisCholestasisMedicineInternal medicineFibrous capsule of GlissonGastroenterologyCancer researchPathologyEndocrinology

Abstract

fetched live from OpenAlex

mice with the TNF-α inhibitor etanercept reduced the presence of activated stellate cells and alleviated liver fibrosis after BDL. Together, these data suggest that iRhom2-mediated inhibition of TNFR signaling protects against liver fibrosis.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.044
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.021
GPT teacher head0.266
Teacher spread0.245 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it