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Record W2983812559

Benzo[a]pyrene as a behaviour altering compound in zebrafish

2019· article· en· W2983812559 on OpenAlexaff
Jeffrey Krook

Bibliographic record

VenueStudent Research Proceedings · 2019
Typearticle
Languageen
FieldEnvironmental Science
TopicFish Ecology and Management Studies
Canadian institutionsMacEwan University
Fundersnot available
KeywordsBoldnessZebrafishDanioBenzo(a)pyreneShoalBiologyZoologyEcologyPyrenePsychologyBiochemistryGene
DOInot available

Abstract

fetched live from OpenAlex

Crude oil and other petroleum products contain the polycyclic aromatic hydrocarbon Benzo[a]Pyrene (BaP). This toxin affects the metabolism, physiology, and morphology of numerous species. However, the impact of BaP exposure on behaviour in aquatic organisms remains largely unexplored. Some studies suggest exposure may lead to increased boldness or aggression in marine fish. Shoal cohesion in zebrafish has been well explored and pharmacologically validated as a method of measuring boldness and anxiety-like behaviours, with increased boldness presenting as a more spread out shoal, with a greater inter-individual distance. To further explore the impact of BaP on behaviour in a freshwater species, we exposed shoals of 5 zebrafish (Danio rerio) to doses of 2.5, 25, and 250 µM of BaP and examined shoaling behaviour. Acute exposure (30 minutes) to BaP (250 µM) reduced shoal tightness, increasing the inter-individual distance. This suggests an increase in boldness due to acute BaP exposure, and an impact of BaP on social behaviour in zebrafish. This study confirms that acute exposure to BaP may directly impact behaviour, with the candidate mechanism to be explored in further studies.   Faculty Mentor: Trevor Hamilton Department: Psychology

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.012
Threshold uncertainty score0.023

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.046
GPT teacher head0.370
Teacher spread0.325 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations0
Published2019
Admission routes1
Has abstractyes

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