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Record W2984079034 · doi:10.7554/elife.39856.048

Author response: Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances

2018· peer-review· en· W2984079034 on OpenAlexaff
Paul R. H. J. Timmers, Ninon Mounier, Kristi Läll, Krista Fischer, Ning Zheng, Xiao Feng, Andrew D. Bretherick, David W. Clark, Mawussé Agbessi, Habibul Ahsan, Isabel Alves, Anand Kumar Andiappan, Philip Awadalla, Alexis Battle, Marc Jan Bonder, Dorret I. Boomsma, Mark Christiansen, Annique Claringbould, Patrick Deelen, Jenny van Dongen, Tõnu Esko, Marie-Julie Favé, Lude Franke, T Frayling, Sina A. Gharib, Greg Gibson, Gibran Hemani, Rick Jansen, A Kalnapenkis, Silva Kasela, Jarno L. T. Kettunen, Y Kim, Holger Kirsten, Péter Kovács, Knut Krohn, Jaanika Kronberg-Guzman, Viktorija Kukushkina, Zoltán Kutalik, Mika Kähönen, B Lee, Terho Lehtimäki, Markus Loeffler, Urko M. Marigorta, Andres Metspalu, Joyce B. J. van Meurs, Lili Milani, Martina Müller‐Nurasyid, Matthias Nauck, Michel G. Nivard, Brenda W.J.H. Penninx, Markus Perola, Natalia Pervjakova, Brandon L. Pierce, Joseph E. Powell, Holger Prokisch, BM Psaty, Olli T. Raitakari, Susan M. Ring, Samuli Ripatti, Olaf Rötzschke, Sina Rüeger, A Saha, Markus Scholz, Katharina Schramm, Ilkka Seppälä, Michael Stümvoll, Patrick Sullivan, Alexander Teumer, Joachim Thiery, Anke Tönjes, Joost Verlouw, Peter M. Visscher, Urmo Võsa, Uwe Völker, Hanieh Yaghootkar, Jian Yang, Biao Zeng, F Zhang, Xia Shen, James F. Wilson, Peter K. Joshi

Bibliographic record

Venuenot available
Typepeer-review
Languageen
FieldMedicine
TopicBirth, Development, and Health
Canadian institutionsOntario Institute for Cancer ResearchCentre for Global Health Research
Fundersnot available
KeywordsPopulationBiologyEvolutionary biologyMedicine

Abstract

fetched live from OpenAlex

Genomic associations with lifespan principally reflect heart disease/smoking/dementia but not other cancers, and distinguish lifespan differences of five years between top/bottom deciles of a score derived from DNA alone.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.006
metaresearch head score (Gemma)0.040
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.136
Threshold uncertainty score0.455

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0060.040
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0020.002
Scholarly communication0.0030.002
Open science0.0020.002
Research integrity0.0100.009
Insufficient payload (model declined to judge)0.1360.058

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.113
GPT teacher head0.372
Teacher spread0.259 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2018
Admission routes1
Has abstractyes

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