Bibliographic record
Abstract
A 65-year-old female patient presented with a 6-week history of effort-related angina (Canadian Cardiovascular Society Class II). She gave no past cardiac history and was not on any medications. She is a lifelong non-smoker. On examination, she was in sinus rhythm, with a heart rate of 76 b.p.m. and a blood pressure of 135/85 mmHg. Investigations revealed that she had a normal full blood count, normal renal and liver function, and normal thyroid function. Her total cholesterol was 200 mg/dL, low-density lipoprotein 110 mg/dL, high-density lipoprotein 50 mg/dL, and glucose 80 mg/dL. The ECG showed an anterior T-wave inversion in V3 and V4. The 2D echo showed a mildly impaired left ventricular function with anterior hypokinesia and an ejection fraction of 40%. This is a new presentation of angina in a patient that has been shown to have T-wave inversion across the front of the chest and impaired left ventricular dysfunction; therefore, it is important to define the physiology and anatomy to stratify treatment. A stress echo was arranged, which showed an area of reversible ischaemia under stress in the anterior wall. A coronary CT angiography showed an occluded mid-left anterior descending coronary artery. She was started on aspirin 75 mg once daily and atorvastatin 20 mg once daily. In addition, she was started on the beta-blocker metoprolol 25 mg twice daily.1 Metoprolol was started as she gave a history of effort angina, with a high heart rate and a normal blood pressure. The atorvastatin to correct the elevated low-density lipoprotein and aspirin is generally used in stable angina. One month later, there was no improvement because she was still complaining of angina. On examination, she was in sinus rhythm, with a heart rate of 72 b.p.m. and a blood pressure of 110/70 mmHg. Ivabradine was cautiously introduced at a dose of 2.5 mg twice daily. A further increase in the dose of metoprolol was not warranted as her blood pressure was low.2,3 Two weeks later, she was feeling much better, complaining only of occasional angina; heart rate was 62 b.p.m. and blood pressure 120/74 mmHg. The authors didn't receive any financial support in terms of honorarium by Servier for the articles. Conflict of interest: K.F. has received fees, honoraria and travel expenses from Servier, AstraZeneca, Broadview Ventures, CellAegis, Celixir, Taurx and UCB. He is a director of Vesalius Trials Ltd.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".