Viral persistence of mammalian reovirus in cell culture: a model of virus-cell coevolution
Bibliographic record
Abstract
Although mammalian reovirus exhibits only limited pathogenicity in humans, it has been, and still remains, instrumental in studies of viral replication and pathogenesis. Generally considered as cytolytic, this virus can sometimes establish long-term persistent infections in tissue culture. In fact, in this context, it constitutes one widely used model to demonstrate coevolution between virus and host cells. Initially limited to the murine L929 fibroblasts model, further studies in different cell types appeared in the last few years. Establishment of viral persistence could also become a preferred approach to isolate new viruses that are better adapted to their applications in virotherapy, for example as oncolytic agents against human or animal cancers. A better understanding of the persistence phenomenon, especially of viral genes involved, is thus essential. The development of new tools, such as reverse genetics, appears very promising to achieve these objectives. Actually, this last approach allows us to establish the biological significance of mutations found on viruses selected during viral persistence.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".