Psoriatic Arthritis, Psoriatic Disease, or Psoriatic Syndrome?
Bibliographic record
Abstract
Psoriatic arthritis (PsA) is a multifaceted disease. Within this definition, PsA can be recognized by the identification of clinical hallmarks, and generally, rheumatologists diagnose it by the presence of typical skin lesions and articular inflammatory manifestations. This process could be a very easy task especially when some phenotypic manifestations and a detectable objective disease activity are present. Sometimes, the same disease can be very challenging when some manifestations such as pain, fatigue, or even enthesitis are predominant and associated with a less detectable disease activity. The British physician Verna Wright (1928–1998) is considered the father of the spondyloarthropathies. His interest started with PsA, and then with his junior colleagues, he made a fundamental contribution to this spectrum of diseases1. Over the past decade, an increased knowledge of PsA pathogenesis with the identification of various cytokines as targets to be treated has revolutionized the treatment strategy2. Therefore, the possibility of personalized medicine, with different phenotypes or biomarkers, has also been proposed3. Hence, there is a potential unmet need to redefine this condition4. In fact, we have moved from a simplistic concept of “arthritis” associated with psoriasis to a more comprehensive concept of “disease” because of the frequent association with extraarticular manifestations and comorbidities5. In … Address correspondence to Dr. E. Lubrano, Dipartimento di Medicina e Scienze della Salute “Vincenzo Tiberio,” Università degli Studi del Molise, Campobasso, Italy. E-mail: enniolubrano{at}hotmail.com
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.002 | 0.003 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.003 |
| Insufficient payload (model declined to judge) | 0.009 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".