Case of Cronkhite Canada Syndrome - A Non-Inherited Gastrointestinal Polyposis Syndrome
Bibliographic record
Abstract
A 56-year-old male presented with complaints of non-bloody watery diarrhoea, weight loss since past one year and pigmentation over face and distal extremities since eight months.Patient gave history of loose stools, watery, small in quantity, occasionally mixed with blood but not accompanied with mucosa or fat and with frequency of around 10 episodes per day, sometimes even at night.Loose stools were not related to food consumption, mental stress or any drugs.There was no history of fever, nausea, abdominal pain, vomiting.No h/o oral ulcer/ pigmentation.Patient was operated for cataract ten years back.He was non hypertensive and non-diabetic.No past history of psychiatric illness.No similar complaints in any other family member.Consumes mix diet, denies addictions.On physical examination, vitals were within normal limits, he had hyperpigmentation over face, both hands involving both palms and both legs involving soles (Figure -1, 2, 3) alopecia and dystrophic nail changes (Figure -4).No pigmentation was noted in the oral cavity.No signs of vitamin deficiency were seen.His abdomen was soft with no tenderness and it was nondistended with no palpable organomegaly.Rest of the physical examination was not contributory.The laboratory parameters including complete blood counts, renal and liver function tests, serum electrolytes were within normal limits except hypocalcaemia (8 mg/dl; normal range: 8.6-10.5 mg/dl) hypoalbuminemia (2.8 g/dl; normal: 3.5-5 g/dl).To further investigate his condition, special tests were done like ESR: 30; HIV/HBsAg/Anti HCV: Negative; FT3, FT4, TSH: Normal; Serum 8 AM cortisol-normal, Sr. Vit.B12 level: normal, Sr. ANA: negative, USG abdomen: normal.Stool was negative for occult blood.Patient underwent an upper GI endoscopy which was also normal.On colonoscopy, there were multiple polypoidal lesions extending from distal transverse colon till rectum (Figure -5).
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.003 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".