Alzheimer's Disease Diagnosis and Severity Level Detection Based on Electroencephalography Modulation Spectral “Patch” Features
Bibliographic record
Abstract
Over the last two decades, electroencephalography (EEG) has emerged as a reliable tool for the diagnosis of cortical disorders such as Alzheimer's disease (AD). Typically, resting-state EEG (rsEEG) signals have been used, and traditional frequency bands (delta, theta, alpha, beta and gamma) have been explored. Recent studies, however, have suggested that non-conventional bands may lead to improved diagnostic performance. In this work, we propose a new type of features derived from the 2-dimensional modulation spectral domain representation of the rsEEG signal in order to characterize the neuromodulatory deficit emergent with AD. The proposed features are computed as the power in specific "patches" or regions of interest in the power modulation spectrogram, which are shown to be highly discriminant of AD severity levels. The proposed features were compared with traditional features used in the rsEEG AD monitoring literature. Results showed the proposed features not only achieving improved performance at discriminating between healthy normal elderly controls (Nold) and AD patients with varying severity levels, but also at monitoring severity levels (i.e., mild AD versus moderate AD). Moreover, the proposed features were shown to outperform traditional rsEEG features. Finally, we validated the biological origin of the proposed features by using source localization and comparing the obtained results with ones reported in the AD literature.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".