NEUROPATI PERIFER PADA PENYANDANG TALASEMIA DI POLIKLINIK HEMATO-ONKOLOGI RSUP DR. HASAN SADIKIN BANDUNG
Bibliographic record
Abstract
PERIPHERAL NEUROPATHY IN THALASSEMIA PATIENTS AT HAEMATO-ONCOLOGY CLINIC HASAN SADIKIN GENERAL HOSPITAL BANDUNGABSTRACTIntroduction: Thalassemia is an inherited blood disorder with high prevalence that can lead to various neurological complications such as peripheral neuropathy. Peripheral neuropathy in thalassemia patients is commonly subclinical. Chronic hypoxia due to anemia and iron deposition are thought to be the risk factors for neuropathy in thalassemia. Nerve Conduction Study (NCS) is the gold standard in diagnosing peripheral neuropathy.Aims: To identify peripheral neuropathy among thalassemia patients in Hemato-oncology Clinic at Hasan Sadikin General Hospital, Bandung.Method: This was a cross sectional, observational descriptive study conducted on thalassemia patients who regularly underwent blood transfusion in Haemato-oncology Clinic at Hasan Sadikin General Hospital, Bandung. The study was held from November 2017 until March 2018. All subjects who met inclusion criteria and did not meet any exclusion criteria were assessed with neurological examination, Toronto clinical score and NCS.Results: Forty subjects with mean age 21.8±6.4 years old, 57.5% were female. The mean hemoglobin level was 7.3±0.7g/dL and mean ferritin serum level was 5,032±3,423μg/L. The median Toronto clinical s c o r e was 4 (0-7) with normal, mild neuropathy, and moderate neuropathy in 55%, 42.5%, and 2.5% subjects respectively. Ninety percent patients had abnormal NCS examination with axonal degeneration found in 57.5% subjects and polyneuropathy in 82.5% subjects.Discussion: Peripheral neuropathy were found in most adult thalassemia patients. Although, NCS examination is important to established definitive diagnosis and considered to be performed in thalassemia patients to diagnose peripheral neuropathy.Keywords: NCS, peripheral neuropathy, thalassemia, Toronto clinical scoreABSTRAKPendahuluan: Talasemia adalah penyakit kelainan darah herediter dengan prevalensi tinggi dan menimbulkan komplikasi neurologis berupa neuropati perifer. Neuropati perifer pada penyandang talasemia seringkali bersifat subklinis. Hipoksia jaringan akibat anemia kronis dan deposisi besi karena transfusi dicurigai sebagai faktor risiko terjadinya neuropati perifer pada talasemia. Standar baku diagnosis neuropati perifer adalah dengan pemeriksaan Kecepatan Hantar Saraf (KHS).Tujuan: Untuk mengetahui adanya neuropati perifer pada penyandang talasemia di Poliklinik Hemato-OnkologiMedik RSUP Dr. Hasan Sadikin, Bandung.Metode: Penelitian ini bersifat deskriptif observasional, dengan rancangan potong lintang, dilakukan pada subjek penyandang talasemia yang rutin menjalani transfusi di Poliklinik Hemato-Onkologi Medik RSUP Dr. Hasan Sadikin, Bandung. Penelitian dilakukan sejak November 2017 sampai Maret 2018. Seluruh subjek yang memenuhi kriteria inklusi dan tidak memiliki kriteria eksklusi dilakukan pemeriksaan neurologis, skor klinis Toronto dan KHS.Hasil: Sebanyak 40 subjek berusia rerata 21,8±6,4 tahun, 57,5% perempuan. Rerata kadar hemoglobin 7,3±0,7g/ dL dan rerata kadar feritin 5,032±3,423μg/L. Skor klinis neuropati Toronto didapatkan median 4 (0-7) dengan interpretasi tidak ada neuropati, neuropati ringan dan neuropati sedang berturut-turut pada 55%, 42,5%, dan 2,5% subjek. Sebanyak 90% subjek memiliki gambaran KHS abnormal, polineuropati didapatkan pada 82,5% subjek dan gambaran degenerasi aksonal pada 57,5% subjek.Diskusi: Neuropati perifer terjadi pada sebagian besar penyandang talasemia dewasa. Pemeriksaan KHS diperlukan untuk diagnosis pasti dan dipertimbangkan untuk dilakukan pada penyandang talasemia.Kata kunci: KHS, neuropati perifer, skor klinis Toronto, talasemia
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.011 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".