Epigenetic Underpinnings of Freeze Tolerance in the Goldenrod Gall Fly Eurosta Solidaginis and the Goldenrod Gall Moth Epiblema Scudderiana
Bibliographic record
Abstract
The goldenrod gall fly Eurosta solidaginis and gall moth Epiblema scudderiana are cold hardy insects that inhabit stem galls on goldenrod plants and survive subzero temperatures during the winter.Eurosta uses a freeze tolerance strategy where it restricts the formation of ice to extracellular spaces and preserves vital intracellular functions.Epiblema supercools its bodily fluids to remain unfrozen below 0°C.This thesis examined the role of epigenetic enzymes in insect cold hardiness strategies.Cold and subzero temperature exposure in Eurosta resulted in upregulation of several DNA Methyltransferase (DNMT) enzymes, increases in DNMT and Histone Acetyltransferase (HAT) activities, and decreases in Histone Deacetylase (HDAC) and Ten-Eleven Translocation (TET) enzyme activities.Epiblema showed upregulation of several DNMT enzymes with concurrent decreases in DNMT, HAT, and HDAC activities and no change in TET activity.These findings suggest that epigenetic regulation of genes and histones underpins the winter survival strategies of these insects.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".