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Record W2992456978 · doi:10.1038/s41380-019-0529-7

Correction: Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation

2019· article· en· W2992456978 on OpenAlexaff
Joshua C. Bis, Xueqiu Jian, Brian W. Kunkle, Yuning Chen, Kara L. Hamilton‐Nelson, William S. Bush, William Salerno, Daniel Lancour, Yiyi Ma, Alan E. Renton, Edoardo Marcora, John J. Farrell, Yi Zhao, Liming Qu, Shahzad Ahmad, Najaf Amin, Philippe Amouyel, Gary W. Beecham, Jennifer E. Below, Dominique Campion, Laura B. Cantwell, Camille Charbonnier, Jaeyoon Chung, Paul K. Crane, Carlos Cruchaga, L. Adrienne Cupples, Jean‐François Dartigues, Stéphanie Debette, Jean‐François Deleuze, Lucinda A. Fulton, Stacey Gabriel, Emmanuelle Génin, Richard A. Gibbs, Alison Goate, Benjamin Grenier‐Boley, Namrata Gupta, Jonathan L. Haines, Aki S. Havulinna, Seppo Helisalmi, Mikko Hiltunen, Daniel P. Howrigan, M. Arfan Ikram, Jaakko Kaprio, Jan Konrad, Amanda B Kuzma, Eric S. Lander, Mark Lathrop, Terho Lehtimäki, Honghuang Lin, Kari Mattila, Richard Mayeux, Donna M. Muzny, Waleed Nasser, Benjamin M. Neale, Kwangsik Nho, Gaël Nicolas, Devanshi Patel, Margaret A. Pericak‐Vance, Markus Perola, Bruce M. Psaty, Olivier Quenez, Farid Rajabli, Richard Redon, Christiane Reitz, Anne M. Remes, Veikko Salomaa, Chloé Sarnowski, Helena Schmidt, Michael A. Schmidt, Reinhold Schmidt, Hilkka Soininen, Timothy Thornton, Giuseppe Tosto, Christophe Tzourio, Sven J. van der Lee, Cornelia M. van Duijn, Otto Valladares, Badri N. Vardarajan, Li‐San Wang, Weixin Wang, Ellen M. Wijsman, Richard K. Wilson, Daniela Witten, Kim C. Worley, Xiaoling Zhang, Céline Bellenguez, Jean‐Charles Lambert, Mitja Kurki, Aarno Palotie, Mark J. Daly, Eric Boerwinkle, Kathryn L. Lunetta, Anita L. DeStefano, Josée Dupuis, Eden R. Martin, Gerard D. Schellenberg, Sudha Seshadri, Adam C. Naj, Myriam Fornage, Lindsay A. Farrer

Bibliographic record

VenueMolecular Psychiatry · 2019
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicBiological Research and Disease Studies
Canadian institutionsMcGill University and Génome Québec Innovation Centre
FundersNational Institute on AgingAgence Nationale de la Recherche
KeywordsExome sequencingComputational biologyExomeNeuroscienceBiologyBioinformaticsGeneticsMedicineMutationGene

Abstract

fetched live from OpenAlex

A correction to this paper has been published and can be accessed via a link at the top of the paper.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.085
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.061
Threshold uncertainty score0.204

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0040.085
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0020.002
Bibliometrics0.0030.002
Science and technology studies0.0030.002
Scholarly communication0.0030.002
Open science0.0040.002
Research integrity0.0080.011
Insufficient payload (model declined to judge)0.0610.025

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.022
GPT teacher head0.279
Teacher spread0.258 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations10
Published2019
Admission routes1
Has abstractyes

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