Bibliographic record
Abstract
T regulatory cells (Tregs) are a subset of T cell leukocytes that play a key role in modulating the immune system, maintaining tolerance to self-antigens and suppressing excessive immune responses that go on to harm the host.Much like T helper (Th) cells, Tregs belong to a broader class of CD4+ T cells that develop from pluripotent hematopoietic stems cells in the bone marrow and mature in the thymus.Within the context of allergic asthma, Tregs are central to the process of pulmonary regulation by continuously combatting both immunogenic and harmless antigens. By releasing cytokines such as IL-10 and TGF-ß, Tregs modulate the inflammatory Th2-type immune response which, when dysregulated can drive asthma development as well as the hallmark asthmatic signs- airway hyperresponsiveness,bronchoconstriction, and gland hyperplasia/hypersecretion. This review will explore the function of Tregs as well as their modulatory role within allergic asthma.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".