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Record W2993436820 · doi:10.1016/s0140-6736(19)32971-x

Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X): a randomised, placebo-controlled trial

2019· article· en· W2993436820 on OpenAlexaff
Atul Deodhar, Désirée van der Heijde, Lianne S. Gensler, Tae‐Hwan Kim, Walter P. Maksymowych, Mikkel Østergaard, Denis Poddubnyy, Helena Marzo‐Ortega, Louis Bessette, Tetsuya Tomita, Ann N. Leung, Maja Hojnik, Gaia Gallo, Xiaoqi Li, David H. Adams, Hilde Carlier, Joachim Sieper, Frédéric Morin, Proton Rahman, Federico Ariel, Alberto Berman, Judith Carrio, Eleonora Lucero, José Maldonado Cocco, Rodolfo Pardo Hidalgo, Jorge Antonio Aldrete Velasco, Diego Oscar Viola, Johannes Grisar, Heinrich Resch, Clemens Scheinecker, Ana Claudia Melazzi, Luis Roimicher, Antônio Scafuto Scotton, Aaron Alejandro Barrera Rodriguez, Francisco Fidencio Cons Molina, Cassandra M. Skinner, César Pacheco‐Tena, Cesar Ricardo Ramos Remus, Juan Cruz Rizo Rodriguez, Seung‐Jae Hong, Seong Wook Kang, Chang Keun Lee, Eun Bong Lee, Min‐Chan Park, Sang‐Hoon Lee, Eva Dokoupilová, Zdeněk Dvořák, Martina Malcova, Karel Pvelka, Kari K. Eklund, Pentti A. Järvinen, Anna Karjalainen, Leena Paimela, Yoshinori Taniguchi, Tokutaro Tsuda, Kurisu Tada, Hiroaki Dobashi, Kentaro Inui, Yukitaka Ueki, Yoshifuji Matsumoto, Kazuhiro Hatta, Tatsuya Atsumi, Midori Goto, Shigeru Honjo, Kiyoshi Matsui, Yuya Takakubo, Gunther Neeck, Sylke Wagner, Jürgen Braun, Tomasz Blicharshi, Anna Dudek, Pawel Hrycai, Rafal Plebanski, Janina Drabiszcak-Piatkowska, Jan Brzezicki, Marek Krogulec, Daniela Opriș-Belinski, Ana Maria Ramazan, Luminita Tronaru, Marleen G. van de Sande, Galina Matsievskaya, E. A. Schmidt, Marina Stanislav, S. S. Yakushin, О. Б. Ершова, Andrey Rebroy, Melvin Churchill, Kathleen P. Flint, Maria Greenwald, Mary P. Howell, Jeffrey Kaine, Alan Kivitz, Steven J. Klein, Eric C. Mueller, Eric Peters, Roel Querubin, Michael E. Sayers, Craig D. Scoville, Joseph C. Shanahan, Richard Roseff, John E. Hull, Jyothi Mallepalli, Mohamed Bassam Sebai, Steven C. Kimmel, David H. Goddard, Philip J. Mease, Mark D. Harris, Arthur R. Mabaquiao, Roger J. Diegel, Christine Thai, Tania L. Rivera, Amarilis Perez‐De Jesus, Oscar Soto‐Raices, Ramon Toro-Torres, Carlos Pantojas

Bibliographic record

VenueThe Lancet · 2019
Typearticle
Languageen
FieldMedicine
TopicSpondyloarthritis Studies and Treatments
Canadian institutionsUniversité LavalUniversity of Alberta
FundersEli Lilly and Company
KeywordsIxekizumabAxial spondyloarthritisMedicinePlaceboRandomized controlled trialRadiographyInternal medicinePhysical therapySurgerySecukinumabArthritisAlternative medicinePathologyPsoriatic arthritisSacroiliitis

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.015
Threshold uncertainty score0.635

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.241
Teacher spread0.231 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations214
Published2019
Admission routes1
Has abstractno

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