ALTERED DYNAMIC TIBIOFEMORAL CONTACT PATH LENGTH IN ACL DEFICIENT KNEES
Bibliographic record
Abstract
INTRODUCTION Osteoarthritis (OA) is a degenerative joint disease characterised by the irreversible degradation of cartilage. Ligament injuries in the knee are a known risk factor for post-traumatic OA (PTOA), 1 the aetiology of which may be due to a combination of altered mechanical and biological factors. In this study, we investigated how anterior cruciate ligament (ACL) tear affects the relative motion of the subchondral bone surfaces in the knee (i.e., “surface interactions”), which is abnormal in ACL-deficient animal models. 2 Tibiofemoral contact path was calculated based on the relative surface motions. We hypothesised that contact path length and shape are altered in ACL-deficient subjects. METHODS Two ACL-deficient subjects and one healthy control subject (male, ages 34-55) underwent magnetic resonance (MR) imaging scans (3T FIESTA sequence) of both knees, then performed walking trials on an instrumented treadmill. During the walking trials, ground reaction force data were collected and fluoroscopy images from two separate views of the knee were taken. Using Amira (VSG, Germany), 3D models of the tibia and femur were generated from segmented MR images, and the in vivo bone alignments were determined using AutoScoper (Brown University, RI). For each in vivo frame, tibiofemoral proximity was mapped in Matlab (version R2013a, Natick, MA). Weighted centroids were calculated for each of the four tibiofemoral surfaces, with closer proximities having a higher weighting. The weighting factor used was w = (15 mm – proximity) 3 , counting only proximities less than 15 mm. Contact path was defined as the path that the weighted centroid made across the frames analyzed. Differences in contact path between left and right knees were assessed qualitatively for each of the subjects. RESULTS For the healthy control subject, contact paths were similar between knees, and were in a straight line, primarily in the anterior-posterior direction. In the two ACL-deficient subjects, the unaffected limb contact path displayed a shape similar to the control limbs. In contrast, the paths in the affected knees were shorter, were not consistently in the same location, and underwent greater mediolateral excursions. DISCUSSION AND CONCLUSIONS The qualitative results from three subjects support the hypothesis that contact path location and direction may be altered in ACL-deficient individuals. The changes in contact path show similarities to past studies with animal models. 2 There exist limitations in the ability to measure surface interactions, as only a small portion of the gait cycle can be analyzed using the dual-fluoroscopy system. Despite this, the dual-fluoroscopy method of bone tracking is superior to traditional marker-based motion capture systems, as it is more accurate than marker-based methods. The results suggest that there may be a correlation between ACL status and contact path shape during level walking. Future studies will increase the number of subjects and explore means of comparing contact paths quantitatively. Identification of associations between contact path shape and severity of joint damage may provide new insight into the pathogenesis of osteoarthritis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".