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Record W2994038387 · doi:10.1073/pnas.1917908116

Behavior is the ultimate arbiter: An alternative explanation for the inhibitory effect of fluoxetine on the ovulatory homolog model of orgasm in rabbits

2019· letter· en· W2994038387 on OpenAlexaff
Gonzalo R. Quintana, Conall E. Mac Cionnaith, James G. Pfaus

Bibliographic record

VenueProceedings of the National Academy of Sciences · 2019
Typeletter
Languageen
FieldPsychology
TopicNeuroendocrine regulation and behavior
Canadian institutionsConcordia University
Fundersnot available
KeywordsOrgasmFluoxetineInhibitory postsynaptic potentialSerotonin reuptake inhibitorArbiterPharmacologyInternal medicineSerotoninEndocrinologyPsychologyMedicineComputer scienceSexual dysfunctionReceptor

Abstract

fetched live from OpenAlex

Pavlicev et al. (1) offer an experimental test of the ovulatory homolog model of female orgasm in rabbits. While we appreciate the importance of designing animal models of such elusive phenomena, there are several issues we would like to address. Pavlicev et al. tested whether a daily dose of the selective serotonin reuptake inhibitor (SSRI) would have a dose-dependent effect on the number of contact ovulations in the female rabbit. Upon finding no such effect, the groups were pooled together. This yielded a statistically significant reduction in contact ovulations but also results in several issues. First, the experimental and control groups were small and unbalanced, which … [↵][1]1To whom correspondence may be addressed. Email: gonzalo.qz{at}gmail.com. [1]: #xref-corresp-1-1

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.005
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.007
Threshold uncertainty score0.010

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.005
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.000
Science and technology studies0.0010.002
Scholarly communication0.0010.001
Open science0.0010.000
Research integrity0.0070.005
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.084
GPT teacher head0.369
Teacher spread0.285 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2019
Admission routes1
Has abstractyes

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