Reply to Pitt and Lee: Occupancies of Ca <sup>2+</sup> in complexes of calmodulin with voltage-gated sodium channels
Bibliographic record
Abstract
In PNAS, we describe a crystal structure of Ca2+-loaded calmodulin (Ca2+/CaM) in complex with the C-terminal region (CT) of the voltage-gated sodium channel NaV1.5 (1). We contrasted our findings with those of Wang et al. (2) for the following reasons: The title and abstract had suggested a structure of Ca2+/CaM in complex with NaV CTs, and the corresponding Protein Data Bank (PDB) files (4JPZ and 4JQ) contain fully occupied Ca2+ ions in EF hands 3 and 4, which is not supported by the conformation and electron density. A similar comparison was previously made by Hovey et al. (3), who concluded that the structures by … [↵][1]1To whom correspondence may be addressed. Email: petegem{at}mail.ubc.ca. [1]: #xref-corresp-1-1
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.007 | 0.021 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.004 |
| Scholarly communication | 0.003 | 0.006 |
| Open science | 0.004 | 0.002 |
| Research integrity | 0.018 | 0.038 |
| Insufficient payload (model declined to judge) | 0.004 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".