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Record W2996108641 · doi:10.1016/j.bja.2019.11.025

Integration of the Duke Activity Status Index into preoperative risk evaluation: a multicentre prospective cohort study

2019· article· en· W2996108641 on OpenAlexafffund
Duminda N. Wijeysundera, W. Scott Beattie, Graham S. Hillis, Tom Abbott, Mark Shulman, Gareth L. Ackland, C. David Mazer, Paul S. Myles, Rupert M. Pearse, Brian H. Cuthbertson, P.S. Myles, Sophie Wallace, Paddy Farrington, Bruce Thompson, Mathew J. Ellis, B. Borg, Ross Kerridge, Janice G. Douglas, James R. Brannan, Jeffrey J. Pretto, M.G. Godsall, N. Beauchamp, Sandra L. Allen, A. Kennedy, E. Wright, J. Malherbe, Hilmy Ismail, Bernhard Riedel, Andrew Melville, H. Sivakumar, A. Murmane, K. Kenchington, Y. Kirabiyik, Usha Gurunathan, C. Stonell, K. Brunello, Katherine T. Steele, Oystein Tronstad, P. Masel, Annette Dent, Emma Smith, A Bodger, M. Abolfathi, P Sivalingam, Andrew P. Hall, Thomas Painter, S. Macklin, Adrian D. Elliott, Anna María Claverol Carrera, N Terblanche, Susan C. Pitt, Jason M. Samuels, C. Wilde, Kate Leslie, Andrew MacCormick, David E. Bramley, Anne Marie Southcott, Jonathan Grant, H. Taylor, Samantha Bates, Michael Towns, Anna Tippett, Fray F. Marshall, J. Kunasingam, Anmol Yagnik, C. Crescini, S. Yagnik, Colin J. L. McCartney, Stephen Choi, Priya Somascanthan, K. Flores, Keyvan Karkouti, Hance Clarke, Angela Jerath, Stuart A. McCluskey, Marcin Wąsowicz, Lauren Day, Janneth Pazmino‐Canizares, Paul Oh, R. Belliard, L. Lee, K. Dobson, Vincent Chan, Richard Brull, Noam Ami, Matthew B. Stanbrook, K. Hagen, Douglas Campbell, Timothy G. Short, J. Van Der Westhuizen, Kushlin Higgie, Helen Lindsay, R. Jang, Chris Ho Ming Wong, Davina McAllister, M Ali, Jitendra Kumar, Ellen Waymouth, C. Kim, J. Dimech, Michelle Lorimer, Joyce Tai, R. Miller, R. Sara, A. Collingwood, Sue Olliff, S. Gabriel, Helen Houston, Paul Dalley, Sally Hurford, Anna Hunt, Lynn Andrews, Leanlove Navarra, A. Jason-Smith, N. McMillan, G. Back, Bernard Croal, M. Lum, Daniel Martín, Sarah‐Naomi James, Helder Filipe, M. Pinto, S. Kynaston, M. Phull, Christian M. Beilstein, Phoebe Bodger, Kirsty Everingham, Ya‐Han Hu, Edyta Niebrzegowska, C. Corriea, Thais Creary, Marta Januszewska, Tahania Ahmad, J. Whalley, Richard Haslop, Jane E. McNeil, A. Brown, Neil MacDonald, M. Pakats, Kathryn Greaves, Shaman Jhanji, R. Raobaikady, Ethel Black, Martin Rooms, H. Lawrence, Maria Koutra, Katrina Pirie, M. Gertsman, Sandy Jack, Michael Celinski, Denny Levett, Marcia Edwards, Karen Salmon, Clare Bolger, Lisa Loughney, Leanne Seaward, Hannah Collins, B. Tyrell, N. Tantony, Kim Golder, Robert Stephens, L. Gallego-Paredes, Anna Reyes, Ana Gutierrez del Arroyo, Ashok Raj, Rhiannon Lifford, Elizabeth Torres, A. Ambosta, Magda Melo, Muhammad Mamdani, Kevin E. Thorpe, Michael P. W. Grocott, Harindra C. Wijeysundera

Bibliographic record

VenueBritish Journal of Anaesthesia · 2019
Typearticle
Languageen
FieldMedicine
TopicCardiac, Anesthesia and Surgical Outcomes
Canadian institutionsToronto Western HospitalHealth Sciences CentreToronto Rehabilitation InstituteSunnybrook Health Science CentreUniversity of TorontoUniversity Health NetworkToronto General HospitalSt. Michael's Hospital
FundersDepartment of Family and Community Medicine, University of TorontoMedical Research CouncilCanadian Institutes of Health ResearchOntario Ministry of Research, Innovation and ScienceUnited Kingdom Clinical Research CollaborationMonash UniversityOntario Ministry of Research and InnovationRoyal College of AnaesthetistsNational Institute for Health and Care ResearchToronto East General Hospital FoundationUniversity of TorontoRoyal College of Physicians and Surgeons of CanadaBritish Heart FoundationMedical Research Council CanadaNational Institute of Academic AnaesthesiaOntario Ministry of Health and Long-Term CareAustralian and New Zealand College of AnaesthetistsHeart and Stroke Foundation of Canada
KeywordsMedicineOdds ratioConfidence intervalInternal medicineMyocardial infarctionCohort studyProspective cohort studyCohortLogistic regressionOddsPhysical therapyCardiology

Abstract

fetched live from OpenAlex

BACKGROUND: The Duke Activity Status Index (DASI) questionnaire might help incorporate self-reported functional capacity into preoperative risk assessment. Nonetheless, prognostically important thresholds in DASI scores remain unclear. We conducted a nested cohort analysis of the Measurement of Exercise Tolerance before Surgery (METS) study to characterise the association of preoperative DASI scores with postoperative death or complications. METHODS: The analysis included 1546 participants (≥40 yr of age) at an elevated cardiac risk who had inpatient noncardiac surgery. The primary outcome was 30-day death or myocardial injury. The secondary outcomes were 30-day death or myocardial infarction, in-hospital moderate-to-severe complications, and 1 yr death or new disability. Multivariable logistic regression modelling was used to characterise the adjusted association of preoperative DASI scores with outcomes. RESULTS: The DASI score had non-linear associations with outcomes. Self-reported functional capacity better than a DASI score of 34 was associated with reduced odds of 30-day death or myocardial injury (odds ratio: 0.97 per 1 point increase above 34; 95% confidence interval [CI]: 0.96-0.99) and 1 yr death or new disability (odds ratio: 0.96 per 1 point increase above 34; 95% CI: 0.92-0.99). Self-reported functional capacity worse than a DASI score of 34 was associated with increased odds of 30-day death or myocardial infarction (odds ratio: 1.05 per 1 point decrease below 34; 95% CI: 1.00-1.09), and moderate-to-severe complications (odds ratio: 1.03 per 1 point decrease below 34; 95% CI: 1.01-1.05). CONCLUSIONS: A DASI score of 34 represents a threshold for identifying patients at risk for myocardial injury, myocardial infarction, moderate-to-severe complications, and new disability.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.005
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.010
Threshold uncertainty score0.020

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.005
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.002
Bibliometrics0.0010.002
Science and technology studies0.0010.001
Scholarly communication0.0020.001
Open science0.0010.001
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.273
Teacher spread0.265 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations164
Published2019
Admission routes2
Has abstractno

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