Neuroinflammation and Parkinson’s Disease: Understanding the Inflammatory Process Induced by Chronic Peripheral Injection of LPS in LRRK2 G2019S KI Mice in Correlation with Age
Bibliographic record
Abstract
Parkinson' disease is a progressive neurodegenerative disease arising from a collective effect of advancing age, genetic vulnerabilities and environmental toxins.The objective of the current study was to elucidate a synergistic effect of the advanced age, G2019S mutation and immunological stress (LPS) on neuroinflammation.In the present study, male mice were given five intraperitoneal injections of 250mg/kg of LPS (or saline) every alternate day across the two levels of the age and genotype (age; old vs young, genotype; WT vs G2019S).In line with our expectation, there was a significant loss of TH+ cells in old-G2019S mice that received LPS compared to the young-WT that received saline.There was a significant effect of age and genotype on baseline locomotor activity of these animals.Age and genotype predominantly affected other aspects like increased CX3CR1 expression and increased SiRT3 expression in SNc.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".