An 11-month-old boy with transaminitis
Bibliographic record
Abstract
An 11-month-old male infant had isolated transaminitis on lab investigations obtained during a viral illness with clear nasal discharge, mild cough, and fever. His alanine aminotransferase (ALT) was 203 IU/L (normal 13 to 45 IU/L) and aspartate aminotransferase (AST) was 224 IU/L (normal < 110 IU/L). He was otherwise well and returned to baseline health within a few days. Despite remaining asymptomatic, transaminitis persisted in the following months. He was the product of a dizygotic twin gestation, born full-term by caesarean section. Both twins were healthy neonates. His parents were from East India and were nonconsanguineous. Repeated examination over the next 6 months continued to be unremarkable: at 17 months, the child appeared well and had no jaundice. Abdomen was soft and nontender, with no organomegaly. Muscle bulk, tone, and reflexes were normal in all limbs. At 17 months, his weight was 14 kg (>95th percentile) and height was 82 cm (50th to 75th percentile). He met all developmental milestones; crawling at 7 months, pulling to stand at 9 months and walking independently between 12 and 14 months of age. No hepatic abnormalities were found on abdominal ultrasound or initial laboratory investigations of virology, metabolic screen, and autoimmune markers. Further neuromuscular investigation demonstrated an elevated creatine kinase (CK) of 5026 U/L (normal 20 to 200 U/L), gradually declining ALT (136 IU/L) and normal AST (104 IU/L). Further testing revealed the diagnosis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.003 | 0.001 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.004 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".