Comparison of Vascular Reactivity Profiles in the Superior Mesenteric Artery and Aorta of Normal and Insulin Resistant Wistar Rats: Role of Cyclooxygenase
Bibliographic record
Abstract
Regulation of vascular tone in the superior mesenteric artery (SMA) is an important contributor to elevating blood pressure secondary to insulin resistance. Although narrower than the aorta, it is debatable whether the SMA is a conduit or resistance vessel. In fructose‐fed rats, an animal model of the metabolic syndrome, the contribution of cyclooxygenase (COX) isoforms to vascular reactivity in both aorta and SMA is unclear. We evaluated and compared the effects of COX‐1 and 2 on (PE) phenylephrine‐evoked contraction in the aorta and SMA of 9‐week fructose‐fed male rats. Following induction of insulin resistance and increased systolic blood pressure, isolated aorta and SMA rings were incubated with a selective COX‐2 inhibitor NS‐398 (10 −6 M) and non‐selective inhibitor indomethacin (10 −5 M). Responses to PE (10 −9 – 10 −4 M) were obtained prior to and after treatment. We also studied the changes in relaxation to ACh in SMA in the presence of indomethacin. Contraction to PE was reduced in both the aorta and SMA of fructose‐fed rats in presence of either NS‐398 or indomethacin as compared to untreated rings. Conversely, inhibition of COX also improved endothelium‐ dependent relaxation in the SMA of fructose‐fed rats suggesting a proconstrictor role for COX‐2‐catalyzed prostanoids. In conclusion our results point to a conduit role for the SMA in vasoconstriction, which is similar to that observed in the aorta.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".