Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
fundA Canadian funder is recorded on the work.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.
VenueUNC Libraries · 2024
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsnot available
FundersCarolina Population Center, University of North Carolina at Chapel HillNational Institute of Child Health and Human DevelopmentNational Institute of Environmental Health SciencesNational Institute of Neurological Disorders and StrokeNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institute of Allergy and Infectious DiseasesInstituto de Salud Carlos IIIFaculty of Medicine, Dentistry and Health Sciences, University of Western AustraliaCambridge Institute for Medical Research, University of CambridgeCanadian Institutes of Health ResearchManchester Biomedical Research CentreAgricultural Research ServiceTerveyden ja hyvinvoinnin laitosGovernment of Western AustraliaTaysRegion SjællandPaavo Nurmen SäätiöNational Center for Research ResourcesDiabetesliittoSydäntutkimussäätiöUniversitetet i BergenInstituto Mexicano del Seguro SocialSamfundet FolkhälsanEmil Aaltosen SäätiöSigne ja Ane Gyllenbergin SäätiöNovo NordiskGeneralitat de CatalunyaUniversity of TorontoGeneralitat ValencianaDeutsche ForschungsgemeinschaftMurdoch UniversityNederlandse Organisatie voor Wetenschappelijk OnderzoekMinisterio de Ciencia e InnovaciónConsejo Nacional de Ciencia y TecnologíaErasmus Medisch CentrumAmerican Diabetes AssociationErasmus Universiteit RotterdamNational Health and Medical Research CouncilOulun YliopistoEdith Cowan UniversitySuomen KulttuurirahastoStrategiske ForskningsrådZonMwCurtin University of TechnologyNational Institute on Drug AbuseHelse- og OmsorgsdepartementetMarch of Dimes FoundationKelaBergens ForskningsstiftelseRaine Medical Research FoundationKuopion Yliopistollinen SairaalaH. Lundbeck A/SUniversity of BristolLundbeckfondenUniversity College LondonWellcome TrustVetenskapsrådetAsthma and Lung UKNational Institute for Health and Care ResearchInstituto de Seguriidad y Servicios Sociales de los Trabadores del EstadoGreat Ormond Street Hospital for ChildrenNIHR Cambridge Biomedical Research CentreInnovationsfondenGovernment of OntarioJuvenile Diabetes Research Foundation InternationalCompute CanadaFoundation for Cardiovascular ResearchFinska LäkaresällskapetYrjö Jahnssonin SäätiöNovo Nordisk Foundation Center for Basic Metabolic ResearchUniversity of Notre DameSouthern California Environmental Health Sciences CenterNational Institutes of HealthStiftelsen Kristian Gerhard JebsenNorges ForskningsrådAustralian GovernmentTampereen TuberkuloosisäätiöHeart and Stroke Foundation of CanadaSocialdepartementetEuropean CommissionHelsingin YliopistoU.S. Department of AgricultureMedical Research CouncilFundació la Marató de TV3Juho Vainion SäätiöAmerican Heart AssociationChildren's Hospital of Philadelphia
KeywordsChildhood obesityMeta-analysisAssociation (psychology)Genome-wide association studyGeneticsBiologyGenetic associationObesityEvolutionary biologyPsychologyMedicineGeneSingle-nucleotide polymorphismGenotypeOverweight
Abstract
fetched live from OpenAlexAlthough hundreds of genome-wide association studies-implicated loci have been reported for adult obesity-related traits, less is known about the genetics specific for early-onset obesity and with only a few studies conducted in non-European populations to date. Searching for additional genetic variants associated with childhood obesity, we performed a trans-ancestral meta-analysis of 30 studies consisting of up to 13 005 cases (≥95th percentile of body mass index (BMI) achieved 2-18 years old) and 15 599 controls (consistently <50th percentile of BMI) of European, African, North/South American and East Asian ancestry. Suggestive loci were taken forward for replication in a sample of 1888 cases and 4689 controls from seven cohorts of European and North/South American ancestry. In addition to observing 18 previously implicated BMI or obesity loci, for both early and late onset, we uncovered one completely novel locus in this trans-ancestral analysis (nearest gene, METTL15). The variant was nominally associated with only the European subgroup analysis but had a consistent direction of effect in other ethnicities. We then utilized trans-ancestral Bayesian analysis to narrow down the location of the probable causal variant at each genome-wide significant signal. Of all the fine-mapped loci, we were able to narrow down the causative variant at four known loci to fewer than 10 single nucleotide polymorphisms (SNPs) (FAIM2, GNPDA2, MC4R and SEC16B loci). In conclusion, an ethnically diverse setting has enabled us to both identify an additional pediatric obesity locus and further fine-map existing loci.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.387
Threshold uncertainty score0.631
Codex and Gemma teacher scores by category
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Teacher spread0.232 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
