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Record W2998427337 · doi:10.1101/2020.01.06.896225

Spinal stretch reflexes support efficient control of reaching

2020· preprint· en· W2998427337 on OpenAlexafffund
Jeffrey Weiler, Paul L. Gribble, J. Andrew Pruszynski

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2020
Typepreprint
Languageen
FieldNeuroscience
TopicMotor Control and Adaptation
Canadian institutionsWestern University
FundersNatural Sciences and Engineering Research Council of CanadaCanada Research Chairs
KeywordsWristElbowReflexNeuroscienceMotor controlNeurophysiologyComputer scienceMotor systemPhysical medicine and rehabilitationAnatomyPsychologyMedicine

Abstract

fetched live from OpenAlex

Abstract Efficiently controlling the movement of our hand requires coordinating the motion of multiple joints of the arm. Although it is widely assumed that this type of efficient control is implemented by processing that occurs in the cerebral cortex and brain stem, recent work has shown that spinal circuits can generate efficient motor output that supports keeping the hand in a static location. Here, we show that a spinal pathway can also efficiently control the hand during reaching. In our first experiment we applied multi-joint mechanical perturbations to participant’s elbow and wrist as they began reaching towards a target. We found that spinal stretch reflexes evoked in elbow muscles were not proportional to how much the elbow muscles were stretched but instead were efficiently scaled to the hand’s distance from the target. In our second experiment we applied the same elbow and wrist perturbations but had participants change how they grasped the manipulandum, diametrically altering how the same wrist perturbation moved the hand relative to the reach target. We found that changing the arm’s orientation diametrically altered how spinal reflexes in the elbow muscles were evoked, and in such a way that were again efficiently scaled to the hand’s distance from the target. These findings demonstrate that spinal circuits can help efficiently control the hand during dynamic reaching actions, and show that efficient and flexible motor control is not exclusively dependent on processing that occurs within supraspinal regions of the nervous system.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.008

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.032
GPT teacher head0.253
Teacher spread0.221 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5
Published2020
Admission routes2
Has abstractyes

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