New sesquiterpenoids from an endophytic fungus Paraconiothyrium brasiliense ECN258
Bibliographic record
Abstract
Paraconiothyrium brasiliense was a plant endophyte distributing worldwide and has been ever isolated from a wide range of host plants such as Coffea arabica in Brazil, Ginko biloba in Canada, and Prunus spp. in South Africa. Paraconiothyrium brasiliense ECN258 that we used in this study was isolated from a stem of Cinnamomum camphora in Japan. To discover new natural resources for beneficial compounds, we have obtainined endophyte strains more than 400 from various plants in Japan and continue to investigate the metabolites produced by them [1], [2]. In this study, eleven new sesquiterpenoids (1–11) were isolated from cultures of Paraconiothyrium brasiliense ECN258 as well as five known sesquiterpenoids (12–16). The structures of new compounds were elucidated by analyzing IR, MS, NMR, and ECD spectroscopic data. Compounds 1–7 are eremophilane sesquiterpenoids, whereas compounds 8–10 have new or rare carbon frameworks that are probably biosynthesized by rearrangement of eremophilanes. Furthermore, paraconiothyrins K (11) is a C18 compound containing an eremophilane within the backbone. Compounds 1–5 and 8–16 were evaluated for their effects on some nuclear receptors including RXRα, PPARγ, PPARδ, RARα, and LXRα by means of luciferase reporter gene assay for each receptor. Among test compounds, compound 9 exhibited an inhibitory effect on LXRα at the concentration of 50 μM.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.009 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".