Receptores del gusto en la vía respiratoria. Su importancia en homeostasis nasosinusal
Bibliographic record
Abstract
RESUMENEl sistema inmune actúa como un sistema sensorial detectando patógenos invasores.Evidencia reciente sugiere que el sistema inmune y el sistema del gusto utilizan algunos de los mismos receptores quimiosensoriales, la familia 2 de los receptores del gusto amargos (T2R).T2R son receptores acoplados a la proteína G originalmente identificados en las células tipo 2 del gusto en la lengua; sin embargo, la expresión de éstos se sabe se extienden a múltiples órganos y sistemas, incluyendo la vía respiratoria.Estudios básicos y clínicos han demostrado que estos T2Rs son parte de una vía de reconocimiento de patógenos en la vía respiratoria y regulan respuestas innatas múltiples tanto en ratones como en humanos.Se ha encontrado que la isoforma T2R38 (familia 2 del receptor del gusto isoforma 38), la cual se expresa en los cilios móviles que se encuentran en la nariz y senos paranasales, se relaciona de manera importante a la inmunidad innata nasosinusal, a la respuesta a infecciones respiratorias superiores y a la rinosinusitis crónica.Esto nos abre un camino potencial de entender mejor estas patologías muy frecuentes.Palabras clave: Receptores del gusto, receptores T2R, receptores T2R38, inmunidad innata en la vía respiratoria superior, rinosinusitis crónica, células quimiosensoriales solitarias.AbstrAct the immune system acts as a sensory system to detect invading pathogens.recent evidence suggests that the immune and taste systems utilize some of the same chemosensory receptors, namely bitter taste receptors of the taste receptor family 2 (T2R).T2Rs are G-protein coupled receptors originally identified in type 2 taste receptor cells of the tongue, but expression of these t2rs is now known to extend to multiple organ systems, including the airway.basic science and clinical studies are establishing t2rs as part of a novel pathogen detection network in the airway, they are expressed in a variety of airway cell types and regulate multiple innate immune responses in both mice and humans.the t2r isoform, taste receptor family 2 isoform 38 protein (t2r38), which is expressed in motile cilia lining the sinonasal cavity (nose and sinuses), has recently been linked with sinonasal innate immunity, upper respiratory infection and chronic rhinosinusitis (crs) demonstrating their importance into human disease and these very frequent diseases.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".