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Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer’s Disease
Alexa Pichet Binette, Étienne Vachon‐Presseau, John C. Morris, Randall J. Bateman, Tammie L.S. Benzinger, D. Louis Collins, Judes Poirier, John C.S. Breitner, Sylvia Villeneuve, Ricardo Allegri, Fatima Amtashar, Randy Bateman, Sarah Berman, Courtney Bodge, Susan Brandon, William S. Brooks, Jill Buck, Virginia Buckles, Sochenda Chea, Jasmeer P. Chhatwal, Patricio Chrem, Helena C. Chui, Jake Cinco, Clifford Jack, Carlos Cruchaga, Mirelle D’Mello, Tamara Donahue, Jane Douglas, Noelia Edigo, Nilufer Erekin-Taner, Anne M. Fagan, Marty Farlow, Angela Farrar, Howard Feldman, Gigi Flynn, Nick C. Fox, Erin Franklin, Hisako Fujii, Cortaiga Gant, Samantha L. Gardener, Bernardino Ghetti, Alison Goate, Jill Goldman, Brian A. Gordon, Neill Graff-Radford, Julia Gray, Jenny Gurney, Jason Hassenstab, Mie Hirohara, David M. Holtzman, Russ C. Hornbeck, Siri Houeland DiBari, Takeshi Ikeuchi, Snežana Ikonomović, Gina Jerome, Mathias Jucker, Celeste M. Karch, Kensaku Kasuga, Takeshi Kawarabayashi, William E. Klunk, Robert A. Koeppe, Elke Kuder-Buletta, Christoph Laske, Jae‐Hong Lee, Johannes Levin, Daniel S. Marcus, Ralph N. Martins, Neal Scott Mason, Colin L. Masters, Denise Maue-Dreyfus, Eric McDade, Lucy Montoya, Hiroshi Mori, Akem Nagamatsu, Katie Neimeyer, James M. Noble, Joanne Norton, Richard J. Perrin, Marc Raichle, John M. Ringman, Jee Hoon Roh, Stephen Salloway, Peter R. Schofield, Hiroyuki Shimada, Tomoyo Shiroto, Mikio Shoji, Wendy Sigurdson, Hamid R. Sohrabi, Paige Sparks, Kazushi Suzuki, Laura Swisher, Kevin Taddei, Jen C. Wang, Peter Wang, Mike Weiner, Mary Wolfsberger, Chengjie Xiong, Xu Xiong, Angela Tam, Anne Labonté, Anne‐Marie Faubert, Axel Mathieu, Cécile Madjar, Charles Edouard Carrier, Christian Dansereau, Christina Kazazian, Claude Lepage, Cynthia Picard, David Maillet, Diane Michaud, Doris Couture, Doris Dea, A. Claudio Cuello, Alan Barkun, Alan C. Evans, Blandine Courcot, Christine Tardif, Clément Debacker, Clifford R. Jack, David Fontaine, David S. Knopman, Gerhard Maultaup, Jamie Near, Jeannie‐Marie Leoutsakos, Jean‐Robert Maltais, Jason Brandt, Jens C. Pruessner, Laksanun Cheewakriengkrai, Lisa Marie Munter, M. Mallar Chakravarty, Mark A. Sager, Marina Dauar‐Tedeschi, Mark J. Eisenberg, Natasha Rajah, Paul Aisen, Joanne Toussaint, Pedro Rosa‐Neto, Pierre Bellec, Penelope Kostopoulos, Pierre Étienne, Pierre N. Tariot, Pierre Orban, Reisa A. Sperling, Rick Hoge, Ronald G. Thomas, Serge Gauthier, Suzanne Craft, Thomas J. Montine, Vasavan Nair, Véronique D. Bohbot, Vinod Venugopalan, Vladimir Fonov, Yasser Ituria‐Medina, Zaven S. Khachaturian, Eduard Teigner, Elena Anthal, Elsa Yu, Fabiola Ferdinand, Galina Pogossova, Ginette Mayrand, Guerda Duclair, Guylaine Gagné, Holly Newbold‐Fox, Illana Leppert, Isabelle Vallée, Jacob W. Vogel, Jennifer Tremblay‐Mercier, Joanne Frenette, Josée Frappier, Justin Kat, Justin Miron, Karen Wan, Laura Mahar, Leopoldina Carmo, Louise Théroux, Mahsa Dadar, Marianne Dufour, Marie‐Élyse Lafaille‐Magnan, Melissa Appleby, Mélissa Savard, Miranda Tuwaig, Mirela Petkova, Pierre Rioux, Pierre‐François Meyer, Rana El‐Khoury, Renee Gordon, Renuka Giles, Samir Das, Seqian Wang, Shirin Tabrizi, Sulantha Mathotaarachchi, Sylvie Dubuc, Tanya Lee, Thomas Beaudry, Valérie Gervais, Véronique Pagé, Julie Gonneaud, Gülebru Ayrancı, Tharick A. Pascoal, René Desautels, Fatiha Benbouhoud, Eunice Farah Saint‐Fort, Sander C.J. Verfaillie, Sarah Farzin, Alyssa Salaciak, Stéphanie Tullo, Leslie‐Ann Daoust, Theresa Köbe, R. Nathan Spreng, Melissa McSweeney, Nathalie Nilsson, Morteza Pishnamazi, Christophe Bedetti
Bibliographic record
VenueBiological Psychiatry · 2020
Typearticle
Languageen
FieldMedicine
TopicDementia and Cognitive Impairment Research
Canadian institutionsMontreal Neurological Institute and HospitalMcGill UniversityDouglas Mental Health University Institute
FundersCanadian Institutes of Health ResearchFonds de Recherche du Québec - SantéPfizer CanadaGovernment of CanadaDeutsches Zentrum für Neurodegenerative ErkrankungenCanada Research ChairsAlzheimer SocietyPfizerJapan Agency for Medical Research and DevelopmentKorea Health Industry Development InstituteMcGill UniversityFleniNational Institute on AgingAlzheimer's AssociationFoundation for the National Institutes of Health
KeywordsNeuroticismCohortPersonality pathologyDiseaseExtraversion and introversionCognitive declinePsychologyCognitionMedicineDementiaClinical psychologyBig Five personality traitsPersonalityPsychiatryOncologyInternal medicinePersonality disorders
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.016
Threshold uncertainty score0.366
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.049
GPT teacher head0.339
Teacher spread0.290 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations71
Published2020
Admission routes2
Has abstractno