Optimising Leaflet Geometry to Improve Bioprosthetic Aortic Valve Durability
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Bibliographic record
Abstract
Objective: The aim of this study was to assess roles of leaflets geometry on the structural deterioration of bioprosthetic aortic valves (BAVs) in closed configuration. Methods: With a Fung-type orthotropic model, finite element modeling was used to create ten cases. Three parameters were included: the circumferential and radial curvatures and leaflets angle. Parabolic, circular and sline curvatures and six leaflet angles were studied. These parameters are shown in Fig. 1 and summarised in Table 1.Table 1Case numberLeaflet angle (degree)Radial CurvatureCircumferential Curvature154.4linearParabola254.4LinearSpline354.4LinearCircular4-ParabolaCircular5-CircularCircular645.0LinearCircular747.85LinearCircular850.97LinearCircular958.14LinearCircular1062.22LinearCircular Open table in a new tab Results: A circular circumferential curvature led to lower von Mises and compressive stresses in both the coaptation and load bearing areas, reduced tensile stresses in the coaptation regions, and increased tensile stresses in the load bearing areas. A parabolic radial curvature reduced von Mises stresses in the coaptation as well as load bearing regions, reduced compressive stresses in the coaptation and tensile stresses in the load bearing regions, led to a slight increase in the minimized tensile stress in the coaptation regions (1.794 vs. 1.765 MPa) and the minimized compressive stress in the load bearing regions (0.772 vs. 0.768 MPa). Within a range of downward inclination of the leaflets, all stresses in the coaptation regions decreased. A parabolic circumferential curvature, a linear radial curvature, and, for most cases, upward leaflet inclinations were associated with larger contact pressures between the leaflets. Conclusions: The load bearing area and the coaptation regions do not necessarily react similarly when the leaflets geometrical parameters are altered. Considering the mechanics of closed BAVs, structural valve deterioration (SVD) is reduced when leaflets have a parabolic radial curvature and are inclined downward within a range. A parabolic radial curvature and downward leaflet inclination leads to improved durability of BAVs. KEYWORD: ICTEHV-O-03 The authors do not declare any conflict of interest.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it