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Record W3006528002 · doi:10.1212/wnl.0000000000010042

<i>GBA</i> variants in REM sleep behavior disorder

2020· article· en· W3006528002 on OpenAlexafffund
Lynne Krohn, Jennifer A. Ruskey, Uladzislau Rudakou, Etienne Léveillé, Farnaz Asayesh, Isabelle Arnulf, Yves Dauvilliers, Birgit Högl, Ambra Stefani, Christelle Charley-Monaca, Beatriz Abril, Giuseppe Plazzi, Elena Antelmi, Luigi Ferini‐Strambi, Anna Heidbreder, Bradley F. Boeve, Alberto J. Espay, Valérie Cochen De Cock, Brit Mollenhauer, Friederike Sixel‐Döring, Claudia Trenkwalder, Karel Šonka, David Kemlink, Michela Figorilli, Monica Puligheddu, Femke Dijkstra, Mineke Viaene, Wolfgang H. Oertel, Marco Toffoli, Gian Luigi Gigli, Mariarosaria Valente, Jean‐François Gagnon, Alex Désautels, Jacques Montplaisir, Ronald B. Postuma, Guy A. Rouleau, Ziv Gan‐Or

Bibliographic record

VenueNeurology · 2020
Typearticle
Languageen
FieldMedicine
TopicLysosomal Storage Disorders Research
Canadian institutionsHôpital du Sacré-Cœur de MontréalInstitut interdisciplinaire d'innovation technologiqueUniversité de MontréalUniversity of AlbertaUniversité de SherbrookeMcGill University Health CentreMcGill University
FundersNational Institute of Neurological Disorders and StrokeCanadian Glycomics NetworkFonds de Recherche du Québec - SantéBritannia PharmaceuticalsIdorsia PharmaceuticalsDeutsche Parkinson VereinigungSun PharmaSunovionH. Lundbeck A/SServierNational Institutes of HealthConsortium canadien en neurodégénérescence associée au vieillissementCanada First Research Excellence FundMcGill UniversityDeutsche ForschungsgemeinschaftUniversity of OxfordCanadian Institutes of Health ResearchJazz PharmaceuticalsParkinson's UKLittle Family FoundationParkinson CanadaUCB PharmaBoston Scientific CorporationBiogenNational Institute for Health and Care ResearchMedical Research CouncilTeva Pharmaceutical IndustriesEli Lilly and Company
KeywordsREM sleep behavior disorderSleep (system call)PsychologyMedicinePsychiatryClinical psychologyPolysomnographyElectroencephalographyComputer science

Abstract

fetched live from OpenAlex

OBJECTIVE: variants in the risk for isolated REM sleep behavior disorder (iRBD) and conversion to overt neurodegeneration. METHODS: variants on the risk of iRBD, age at onset (AAO), and conversion rates. RESULTS: variant carriers. However, the results on AAO and conversion were based on small numbers and should be interpreted with caution. CONCLUSIONS: variant carriers who will develop a synucleinopathy in the future.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.007
Threshold uncertainty score0.019

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0060.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.028
GPT teacher head0.296
Teacher spread0.268 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations77
Published2020
Admission routes2
Has abstractyes

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