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Record W3007051726 · doi:10.1073/pnas.1916562117

Tunable and precise miniature lithium heater for point-of-care applications

2020· article· en· W3007051726 on OpenAlexafffund
Buddhisha Udugama, Pranav Kadhiresan, Warren C. W. Chan

Bibliographic record

VenueProceedings of the National Academy of Sciences · 2020
Typearticle
Languageen
FieldEngineering
TopicBiosensors and Analytical Detection
Canadian institutionsUniversity of Toronto
FundersCanadian Institutes of Health ResearchNatural Sciences and Engineering Research Council of CanadaGovernment of Canada
KeywordsLithium (medication)Point of carePoint (geometry)Nuclear engineeringMaterials scienceEnvironmental scienceEngineering physicsEngineeringMedicineMathematicsInternal medicineNursing

Abstract

fetched live from OpenAlex

Significance Biochemical techniques are required for a variety of different point-of-care applications, from diagnosing illnesses to manufacturing vaccines. Many of these applications cannot be used in remote locations due to their reliance on electricity for temperature control. Here we have developed a miniature lithium heater, up to 8,000 times smaller than existing technologies, enabling the use of biochemical techniques at the point of care. By using these heaters in a model workflow that detects the presence of a virus, we demonstrate their applicability to a broad range of biochemical techniques that require precise temperature control. This technology may be broadly used, such as in disaster relief camps or mountain expeditions, for diagnostic and therapeutic applications.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.021
Threshold uncertainty score0.115

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.023
GPT teacher head0.259
Teacher spread0.235 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations8
Published2020
Admission routes2
Has abstractyes

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