Effects of mitonuclear combination and thermal acclimation on the energetic phenotype
Bibliographic record
Abstract
Activity of the oxidative phosphorylation complexes rely on intimately associated subunits encoded by the mitochondrial and nuclear genomes. Given the key role of this system in adenosine triphosphate production, genes from both genomes must coevolve. A combination of northern redbelly dace (Chrosomus eos) or finescale dace (C. neogaeus) mitochondrial genome with a C. eos nuclear genome allows for a close examination of a naturally occurring disruption of mitonuclear coevolution. We, therefore, investigated the combined effect of mitonuclear genotypes, acclimation, and temperature on the activity of enzymes linked with the energy metabolism in a sympatric population of wild type and cybrid. As expected, the activity of the nuclear-encoded citrate synthase was only influenced by temperature while the cytochrome c oxidase (composed of nuclear and mitochondrial subunits from wild type and cybrid individuals) responded differently to temperature. This study provides clear evidence of the extent by which mitonuclear coadaptation could influence aerobic metabolism.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".