← Back to cohort
Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial
Michael D. Hill, Mayank Goyal, Bijoy K. Menon, Raul G. Nogueira, Ryan McTaggart, Andrew M. Demchuk, Alexandre Y. Poppe, Brian Buck, Thalia S. Field, Dar Dowlatshahi, Brian van Adel, Richard H. Swartz, Ruchir Shah, Eric Sauvageau, Charlotte Zerna, Johanna M. Ospel, Manish Joshi, Mohammed Almekhlafi, Karla J. Ryckborst, Mark Lowerison, Kathy Heard, David Garman, Diogo C Haussen, Shawna M Cutting, Shelagh B. Coutts, Daniel Roy, Jeremy Rempel, Axel Rohr, Daniela Iancu, Demetrios J. Sahlas, Amy Yu, Thomas Devlin, Ricardó A. Hanel, Volker Puetz, Frank L. Silver, Bruce Campbell, René Chapot, Jeanne Teitelbaum, Jennifer Mandzia, Timothy Kleinig, David Turkel‐Parrella, Donald Heck, Michael Kelly, Aditya Bharatha, Oh Young Bang, Ashutosh P. Jadhav, Rishi Gupta, Donald Frei, Jason Tarpley, Cameron McDougall, Staffan Holmin, Joung‐Ho Rha, Ajit S Puri, Marie‐Christine Camden, Götz Thomalla, Hana Choe, Stephen Phillips, Joseph Schindler, John Thornton, Simon Nagel, Ji Hoe Heo, Sung‐Il Sohn, Marios‐Nikos Psychogios, Ronald F. Budzik, Sidney Starkman, Coleman Martin, Paul Burns, Séan Murphy, George Α. Lopez, Joey English, Michael Tymianski, Philip A. Barber, Eric E. Smith, Simerpreet Bal, Suresh Subramaniam, Steven Peters, P Couillard, Gary Klein, Peter K. Stys, John Wong, Alim P. Mitha, Muneer Eesa, William Morrish, Saad Alqatani, Nima Kashani, Prasanna Venkatesan, Erika Teleg, Amith Sitaram, Brett Graham, Stephen van Gaal, Aimen Moussaddy, Debabrata Chakraborty, Nicholas Maraj, Andrew Loockey, Shuo Chen, Ravinder Singh, Abdulaziz S. Al Sultan, R.M. Asuncion, Dominic Tse, Darshan Doshi, Ondřej Volný, Piyush Ojha, Ankur Wadhwa, Martha Marko, Nishita Singh, Sanchea Wasyliw, Carol Kenney, Supriya Save, Anitha Jambula, Nancy Newcommon, G Hull, Darcy Blackstock, Sharon Kiszczak, L Zimmel, Michelle Wright, Cari Jahraus, Shelly Bohn, Joseph Paul, Oiao Zhang, Craig Doram, Andrea Hanley, Lori Campbell, Ashley Ure, F W Taylor, Dominic Hul, Samuel Wiebe, Marina Saluzzi, Nicole Blenkin, Richard Frayne, Kenneth Butcher, Ashfaq Shuaib, Tom Jeerakathil, Glen C. Jickling, Derek Emery, Richard Owen, Robert Ashforth, Tom Yeo, Trevor Kotylak, Cian O′Kelly, Michael Chow, Muzaffer Siddiqui, Maher Saqqur, Atlantic D’Souza, Mar Lloret, Asif Butt, Ali Zohair Nomani, Hayrapet Kalashyan, Sibi Thirunavukkarasu, Juline Jabs, Paige Fairall, Lori Piquette, A. Laine Green, Gordon Gubitz, Jens O. Heidenreich, Thien Huynh, Jai Shankar, William J. Maloney, Robert Vandorpe, Matthias H. Schmidt, Gwynedd E. Pickett, Adrienne Weeks, J Jarrett, Debbie MacDonald, Joanna Arsenault, Ruth Kinnear, Michael Mayich, Melfort Boulton, María Bres Bullrich, Sebastián Fridman, Ruba Kiwan, Donald Lee, Stephen Lownie, Alexander V. Khaw, Sachin Pandey, Manas Sharma, Luciano A. Sposato, Kevin Wade, Beth Beauchamp, Lindsay Lambourn, Belinda Amato-Marziali, Nicole Daneault, Yan Deschaintre, Laura Gioia, Grégory Jacquin, Céline Odier, Christian Stapf, Jean Raymond, Alain Weill, Marlène Lapierre, Nadia Jadil, Judlène Jolteus, Mark Angle, Mathew Hannouche, Mohamed Badawy, Justin Létourneau, Maria Cortes, Grant Linnell, Donateela Tampieri, Lucy Vieira, Catherine Legault, Liam Durcan, Angela Moore, Erin L. Cole, Claire Magnussen, Kristiana Salmon, Salma Khalil, Isabelle Desloges, Lindsay Waxman, Wynne Abdon, Sonia Lai, Michel Shamy, Grant Stotts, Dylan Blacquière, Howard Lesiuk, Aiman Quateen, Brian Drake, Brian Dewar, Zeinab Daham, Gary Hunter, Lissa Peeling, Ruth Whelan, Aaron Garner, Lilian Urroz, Sharleen Maley, Leanne K. Casaubon, Aleksandra Pikula, Martín del Campo, Joanna D. Schaafsma, Cheryl Jaigobin, Timo Krings, Vítor Mendes Pereira, Ronit Agid, Richard Farb, Libby Kalman, Anne Cayley, Janice E. Williams, Tim Stewart, Karen Misquitta, Daniel Selchen, Thomas R. Marotta, Dipanka Sarma, Walter Montanera, Juluan Spears, Gustavo Saposnik, Pawel Kostyrko, Yangmei Li, Carmen Parra-Farina, Jose Danilo Bengzon Diestro, Steve Verreault, Ariane Mackey, Marie‐Ève Audet, Geneviève Milot, Pascale Lavoie, Jean‐Luc Gariépy, Karine Collard, Annette Haché, Ahmed M. Alshanbari, Josephine Baldwin, Luciana Catanese, Bing Chen, Danielle de Sá Boasquevisque, Aviraj Deshmukh, Jordan Knapman, Shana Lamers, Ramiro Larrazabal, Susan Macmillan, Lauren Mai, Alicia Mattia, Sumiti Nayar, Kuan H. Ng, Wieslaw Oczkowski, Kanjana Perera, Mays Shawawrah, Ashkan Shoamanesh, Gita Sobhi, Nabeel Muzaffar Syed, Noran Taher, Cheyanne Vandervelde, D Pharm, Philip Teal, Oscar Benavente, Laura Wilson, Sharanpal Mann, Samuel Yip, Colleen Murphy, Manraj K. S. Heran, Fabio Settecase, Gary Redekop, Charles S. Haw, Genoveva Maclean, Karina Murray, Rosalin Chiu, Alana M. Flexman, Eilidh Strecha, Yolanda Gayton, Judy Yip, Mark I. Boulos, David J. Gladstone, Julia Hopyan, Houman Khosravani, Herbert Manosalva Alzate, Alisia Southwell, Maneesha Kamra, Kaitlyn Lopes, Arunima Kapoor, Leodante da Costa, Victor X. D. Yang, Erin Dyer, Brenda Knowles, Jennifer Nichols, Jennifer Patterson, Krista A. Cope, Lee Dickerson, Katrina Barton, Kimberly Gray, Ticey N. Massengale, Melanie M. Miller, Cindy Simpson, Sabrina Walker, Chlin R. Tennyson-Yemm, Richard Bellon, Benjamin Atchie, Ian Kaminsky, Duandelyn C. Wilson, Nicolle L. Schraeder, Eric Arias, Lisa M. Kodis, Mark E. Talley, Alex A. Edinger, Tiffany Talley, Ita P. Dempsey, Laurie Williams, Scott A. Williams, Sonny Kupniewski, Brad K. Fasbinder, Joanna M. Snead, Larami Mackenzie, D. Weisman, Osman Kozak, Qaisar A. Shah, Dan Gzesh, Kandan Kulandaivel, John Khoury, Brad Klein, Patricia Bussinger, Lisa Griffin, Ashley L. DePalmo, Cynthia Oliva, Tudor G. Jovin, Cynthia L. Kenmuir, Brian T. Jankowitz, Bradley A. Gross, Marcelo Rocha, Matthew Starr, Merritt Brown, Christine Hawkes, Kavit Shah, Danoushka Tememe, Gregory Walker, Pratit Patel, Bradley Klein, Habibullah Ziayee, Kaustubh Limaye, Lisa Baxendell, Vicki Gilchrist, Patricia Feineigle, Kelsea Toseki Haibach, Cathy Van Every, Shashyat Desai, Maryam Zulfiqar, Linda Gibson‐Young, Sean P. Barrett, Karthikeyan Arcot, Steven DiCrescento, Jeffrey Farkas, Gregory Filipowski, Jennifer Frontera, Danielle Joset, Jeremy Liff, Erica Scher, Cheryl E. Kelly, Akshal Patel, Stephen J. Monteith, Kunakorn Atchaneeyasakul, Adrian M Burgos, Janice Anne Y. Chua, Nathan Gaines, Ileana Grunberg, Judy Guzy, Zuolu Liu, Neil D. Maluste, Lucas Ramírez, Latisha Sharma, M Brown, Colin T. McDonald, Mateo Calderon, Mitch Hargis, Christina Roels, Prabhu D. Emmady, Talat Alvi, Mahesh Jayaraman, Shawna Cutting, Wendy Smith, Susan M. Foley, G Paolucci, Richard Has, Katie Quinn, Lindsey Fuller, Rebecca E. Brierley, Christina C. Watkins, Nicole C. Demir, Alejandro Vargas, Nicholas Osteraas, Becky Holtz, Amin Aghaebrahim, Mohamad Chmayssani, Neeraj S. Naval, Jason S. Day, Scott Dellorso, Benjamin J. Ludwig, Derek J. Schemmel, Nancy Ebreo, Karen Bell, Lanai Lewis, Marjorie Delucia, Michael Frankel, Nirav Bhatt, Nicolas Bianchi, Aaron Anderson, Samir Belagaje, Bernardo Liberato, Srikant Rangaraju, Alhamza R Al‐Bayati, Jonathan A Grossberg, Leah Craft, Kiva Schindler, Erin Schaad, Meagan Schultz, Lorretta Southerly, Shannon Doppelheuer, Jacquelyn Charlton, Jason Faggard, Zuzana Barbret, Ethan DukSoo Han, Robin Walters, Jaydevsinh Dolia, Sleiman El-Jamal, Brendan Eby, Yasir Saleem, Harrison Pearl, Kishan Patel, Haseeb Rahman, Reema Butt, Stephen English, M Howk, Jasmeet Singh, Francesco Massari, Katyucia DeMacedo Rodrigues, Anna Luisa Kühn, Nobl Barazangi, Nick Telischak, Warren Kim, Josh Ross, Nata DeVole, Jessica Redford, Milena Ferreira, Katie Ponting, Helen Shen, Ann Bedenk, Susila Patel, Julia Fernandess, Michael Ke, Ilanit Spokoyny, Billy Gao, David Tong, Xiaomeng Chen, Christine Wong, Jessica Choe, Debbie Summers, Christine Boutwell, Karin Olds, Suzanne Crandall, John Eatman, Naveed Akhtar, W Holloway, J Halpin, Brett Donegan, David Y. Hwang, Emily J. Gilmore, Nils Petersen, Kevin N. Sheth, Stacy Brown, Rachel Beekman, Benjamin P. George, Firas Kaddouh, Guido J. Falcone, Charles Wira, Charles Matouk, Caitlin Loomis, Hardik Amin, Reshma Narula, Adam Jasne, Lauren Sansing, Tijil Agarwal, Sara Jasak, Dominique Fontaine, Zachary A. King, Lindsey Kuohn, Hailey Orgass, Megan Leary, Joan Nye, Kelsey Halbert, Karin Nyström, Kaile Neuschatz, Dawn M. Petrucci, Anna Coppola, Treasure A. Joyce, Sam Hou, Mark S. Umekubo, Catrice M. Nakamura, Renee Ovando, Diana Zúñiga, Yih Lin Nien, Fernando Mayor Basto, Allison E. Arch, Laura W. de Jong, William A. Conrad, Tara C. Abbott, Jay Z. Yao, Scott D. Caganap, John E. Jordan, George P. Teitelbaum, Robert Darflinger, Marianne Bain, Jennifer H. Czerniak, Katherine M. Groezinger, William J. Hicks, Omran Kaskar, Brian Katz, Aaron Loochtan, Peter Pema, Vivek Rai, Nirav Vora, Amanda Brown, Diane Goodman, Barb Danenbergs, Monica Gossett, Jong‐Won Chung, Pyoung Jeon, Keon Ha Kim, Yun Jeong Lim, Hyo Suk Nam, Young Dae Kim, Hyungjong Park, In Gun Hwang, Woo‐Seok Ha, Jin Kyo Choi, Kyungsun Jeong, Hee-Kwon Park, Cindy W. Yoon, Bokyung Kim, Chang-Hyun Kim, Joonsang Yoo, Jeong‐Ho Hong, Sohyeon Kim, Moonkyung Choi, Hyoeun Bae, Jun Seok Lee, Jae‐Joon Lee, Go-Eun Jun, Sujeong Jeon, Peter Mitchell, Nawaf Yassi, Stephen M. Davis, Geoffrey A. Donnan, Mark Parsons, Bernard Yan, Richard Dowling, Steven Bush, Teddy Y. Wu, Darshan Shah, Henry Zhao, Patrick Salvaris, Fana Alemseged, Felix Ng, Cameron Williams, Anna Balabanski, Angela Dos Santos, Jo-Lyn Ng, Amy McDonald, David M. Jackson, Jessica Tsoleridis, Lauren Pesavento, Roy Drew Nurs, Rebecca Scroop, Lavenia Cagi, Jackson Harvey, Michael F. Waters, John Thornton, Robert T. Brennan, Alan O’Hare, Sarah Power, David Williams, Karl Boyle, Barry Moynihan, Ann-Marie Liddy, Margaret Large, Ailbhe Cullen, Roisin Walsh, Emma Martin, Julie Lynch, Sinéad McElroy, Sarah Coveney, Caroline Deegan, Gillian Horgan, Peter J. Kelly, Aoife Laffan, Yudy Llamas-Osorio, Catherine Lynch, Peter Mac Mahon, Michael Marnane, John McCabe, Suzanne Tauro, Sarah Cuddy, Ian Rennie, Graham Smyth, Peter Flynn, Ivan Wiggam, Enda Kerr, Patricia Gordon, Patricia Fearon, Geralt Roberts, Cathy Patterson, Karen E. Adams, Brian Wells, Margaret McFarland, Tiago Moreira, Christina Sjöstrand, Michael V. Mazya, Håkan Almqvist, Nils Wahlgren, Anna Steinberg, Charith Cooray, Einar E. Eriksson, M. Thorén, Boris Keselman, Niaz Ahmed, Åke Holmberg, Maria Axelsson, Annika Berglund, Amir Golsari, Julia Hoppe, Milani Deb‐Chatterji, Bastian Cheng, E Barrow, Eckhard Schlemm, Iris Lettow, Märit Jensen, Dagmar Otto, Kirsten Jaramillo, Hannes Appelbohm, Jens Fiehler, Maxim Bester, Michael Schönfeld, Caspar Brekenfeld, Brigitte Holst, Ginette Wortmann, Friederike Koch, Johannes Gerber, Andrij Abramyuk, Daniel Kaiser, Simon Winzer, Alexandra Prakapenia, Lars‐Peder Pallesen, Timo Siepmann, Kristian Barlinn, Kathrin Haase, Angela Sauer, Jan Liman, Alex Brehm, Volker Maus, Nicole Hollstein, Annika Reinke, Gustav Neitz, Marlena Schnieder, Margret Schwarz, Allam Ibrahim, Julia Müller, Stefanie Meister, Berit Bäumle, Sara Pilgram‐Pastor, Marta Wallocha, Michael C. Stauder, Ekin Celik, Paul Stracke, Nicole Müller, Ralph Weber, Roland Velktamp, Peter A. Ringleb, Miriam Heyse, Hemasse Amiri, Sibu Mundiyanapurath, Min Chen, Elisabeth Bevrle, Perdita Beck, Markus Möhlenbruch, Alphonse R.J. Potvin, Cameron Harris, Chong Wang, Corey Adams, Diana Mayor, D. Melissa Garman, Davis Chau, Jane Wu, Janet Lunn, Liat Bermanis, Lucy Teyes, Marc Constant, Maria Galsim, Michael Helbin, Michelle Leroux, Nicole Felix, Nilima Bendre, Sandra Cuthbert, Steve Brokx, Yichuan Zhang, Trudy Lingham, Yatika Kohli, Michael W. Salter, Joseph Liebeschuetz, Frieder Hofmann, John Constant, Tom Soeder, Kara Snoke, Monica Bologa, Kimberly Stahl, Maria A Graziewicz
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.
Bibliographic record
VenueThe Lancet · 2020
Typearticle
Languageen
FieldMedicine
TopicAcute Ischemic Stroke Management
Canadian institutionsUniversité LavalHôpital de l'Enfant-JésusCentre hospitalier universitaire de QuébecQueen Elizabeth II Health Sciences CentreUniversity of SaskatchewanMcGill UniversityLondon Health Sciences CentreNoNO (Canada)Alberta Hospital EdmontonRoyal University HospitalWestern UniversityUniversity of TorontoSt. Michael's HospitalSunnybrook Health Science CentreMcMaster UniversityDalhousie UniversityUniversity of OttawaUniversity of British ColumbiaHealth Sciences CentreUniversity of CalgaryCentre Hospitalier de l’Université de MontréalUniversity Health NetworkUniversity of Alberta HospitalOttawa HospitalMontreal Neurological Institute and HospitalFoothills Medical Centre
FundersNational Institute of Neurological Disorders and StrokeCanadian Institutes of Health ResearchCovidienMedtronicHeart and Stroke Foundation of CanadaAlberta InnovatesAlberta Innovates - Health Solutions
KeywordsMedicineModified Rankin ScaleStroke (engine)Ischaemic strokeRandomized controlled trialPlaceboFibrinolytic agentClinical trialIschemiaInternal medicineSurgeryTissue plasminogen activatorIschemic stroke
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.038
Threshold uncertainty score0.374
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.047
GPT teacher head0.311
Teacher spread0.264 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itQuick stats
Citations629
Published2020
Admission routes2
Has abstractno