Viscosine: A new microbial flavonoid from marine‐derived, <i>Streptomyces</i> sp. RMS518F
Bibliographic record
Abstract
Abstract During the search for bioactive metabolites from marine sediment derived‐actinomycetes, a new microbial flavonoid 6‐hydroxykaempferol‐3,6‐dimethyl ether, viscosine ( 1 ) was isolated from the marine sediment derived‐actinobacteria RMS518F strain. Structure of the compound ( 1 ) was determined by 1D‐ and 2D‐NMR (1 and 2‐Dimensional Nuclear Magnetic Resonance), mass spectrometry and comparison of these data with literature. Taxonomically, the strain was characterized as Streptomyces carpaticus on the bases of 16S rRNA gene sequence. Biologically, compound ( 1 ) exhibited moderate antimicrobial activity against the Gram‐positive bacteria, Staphylococcus aureus ATCC6538‐P; Bacillus cereus ATCC11778 and Saccharomyces cerevisiae ATCC9080 yeast. Compound ( 1 )was also significantly active against the human colon carcinoma cell line (HCT‐116) and the hepatocellular carcinoma cell line (Hep G2) with IC 50 values of 73.4 and 62.8 μg/mL, respectively compared with the antineoplastic drug (Doxorubicin) (37.6 and 21.6 μg/mL), while no activity has been noticed against the human breast cancer cell line (MCF‐7).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.007 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".