A22 ADVERSE EARLY LIFE EVENTS ARE COMMON IN PATIENTS WITH FUNCTIONAL AND ORGANIC GASTROINTESTINAL DISORDERS
Bibliographic record
Abstract
Abstract Background Stressful events in childhood have been associated with the development of functional gastrointestinal (GI) disorders in adulthood, especially irritable bowel syndrome. The influence of early life adverse events in patients with common organic disorders, such as celiac disease and inflammatory bowel disease (IBD), has been poorly investigated. Aims To evaluate the frequency of early life adverse events in patients with organic and functional gastrointestinal disorders compared to healthy controls. Methods Adult patients with an established diagnosis of IBS (Rome IV criteria), celiac disease and inflammatory bowel disease (IBD) attending a tertiary medical center, as well as healthy volunteers were interviewed by a psychologist. Early life adverse events were assessed during the semi-structured interview using a modified version of the Adverse Childhood Experience (ACE) questionnaire. Number of early life events and the presence of GI and extraintestinal symptoms based on a 10-point Likert scale were quantified. Data are presented as Median (IQR) and n (%). Statistical analysis was performed using Mann-Whitney and Fisher’s exact tests as appropriate. Results Sixty-eight patients (18 IBS, 28 celiac, 22 IBD) and 23 healthy controls were enrolled in the study. Patients with IBS, celiac disease and IBD had increased number of early life events compared with healthy controls (6.5 (4.8–8.3), 5.0 (3.0–9.0), 6.0 (4–8.3) vs 2.0 (1.0–4.0) respectively, p<0.0001). Patients reported a higher number of mental disorders in their mothers (IBS p=0.01; celiac disease p=0.01; IBD p=0.001) and increased number of close family member abusing alcohol or drugs during their childhood (IBS p=0.01; celiac p=0.02; IBD p=0.02) compared to healthy controls. History of sexual abuse was higher in patients with IBS (p=0.01), while history of verbal abuse was higher in patients celiac disease and IBD (p=0.003 and p=0.001, respectively) compared to healthy controls. The number of early life adverse events was strongly correlated with number of GI (r= 0.91; p=0.01) and extra-intestinal (r=0.87; p=0.02) symptoms, but not with symptoms severity. Most patients with IBS (83.3%), celiac disease (89.3%) and IBD (85.7%) reported stressful events before the onset of their disease. Conclusions Adverse events in childhood are frequent in patients with chronic GI disorders, both of functional and organic origin. Furthermore, stressful events often precede their diagnosis. These data strongly suggest that better psychosocial assessment in patients with chronic GI disorders is needed to improve their overall management. Funding Agencies None
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".