AKTIVITAS ANTIMALARIA TANAMAN TALI KUNING (Anamirta cocculus) TERHADAP Plasmodium sp.
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Penyakit malaria merupakan salah satu penyebab kematian pada anak-anak dan dewasa khususnya ibu hamil di daerah tropis. Meningkatnya resistensi parasit terhadap obat malaria yang ada merupakan salah satu penyebab tingginya angka morbiditas dan mortalitas. Karena itulah pengembangan obat malaria yang berasal dari tanaman saat ini gencar, salah satunya dengan pemanfaatan tanaman tali kuning (Anamirta cocculus). Mekanisme antimalaria senyawa berberine pada tanaman tali kuning yaitu dengan menghambat aktivitas telomerase Plasmodium sp pada siklus perkembangan plasmodium intraeritrositik terutama pada tahap tropozoid dan skizon. Senyawa dalam bentuk ammonium kuarterner telah diketahui dapat menghambat pertumbuhan Plasmodium dengan cara memblok transport intraseluler kolin. Senyawa kolin diperlukan untuk biosintesis phospholipid dalam pembentukan membran parasit untuk menutup parasitophorous vacuole, sitosol dan berbagai subseluler kompartemen. Pengeblokan transport kolin ini telah digunakan sebagai salah satu strategi pengobatan malaria.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.005 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it