AKTIVITAS ANTIMALARIA TANAMAN TALI KUNING (Anamirta cocculus) TERHADAP Plasmodium sp.
Bibliographic record
Abstract
Penyakit malaria merupakan salah satu penyebab kematian pada anak-anak dan dewasa khususnya ibu hamil di daerah tropis. Meningkatnya resistensi parasit terhadap obat malaria yang ada merupakan salah satu penyebab tingginya angka morbiditas dan mortalitas. Karena itulah pengembangan obat malaria yang berasal dari tanaman saat ini gencar, salah satunya dengan pemanfaatan tanaman tali kuning (Anamirta cocculus). Mekanisme antimalaria senyawa berberine pada tanaman tali kuning yaitu dengan menghambat aktivitas telomerase Plasmodium sp pada siklus perkembangan plasmodium intraeritrositik terutama pada tahap tropozoid dan skizon. Senyawa dalam bentuk ammonium kuarterner telah diketahui dapat menghambat pertumbuhan Plasmodium dengan cara memblok transport intraseluler kolin. Senyawa kolin diperlukan untuk biosintesis phospholipid dalam pembentukan membran parasit untuk menutup parasitophorous vacuole, sitosol dan berbagai subseluler kompartemen. Pengeblokan transport kolin ini telah digunakan sebagai salah satu strategi pengobatan malaria.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".