Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target
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Abstract
A novel infectious disease, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was detected in Wuhan, China, in December 2019.The disease (COVID-19) spread rapidly, reaching epidemic proportions in China, and has been found in 27 other countries.As of February 27, 2020, over 82,000 cases of COVID-19 were reported, with > 2800 deaths.No specific therapeutics are available, and current management includes travel restrictions, patient isolation, and supportive medical care.There are a number of pharmaceuticals already being tested [1, 2], but a better understanding of the underlying pathobiology is required.In this context, this article will briefly review the rationale for angiotensin-converting enzyme 2 (ACE2) receptor as a specific target.
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The record
- Venue
- Intensive Care Medicine
- Topic
- SARS-CoV-2 and COVID-19 Research
- Field
- Medicine
- Canadian institutions
- University of British ColumbiaArtificial Intelligence in Medicine (Canada)University of TorontoSt. Michael's Hospital
- Funders
- Institute of Circulatory and Respiratory HealthCanadian Institutes of Health ResearchGuangzhou Regenerative Medicine and Health Guangdong LaboratoryNational Natural Science Foundation of ChinaNational Science Foundation
- Keywords
- MedicineAngiotensin-converting enzyme 2Peptidyl-Dipeptidase ASevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Pain medicineCoronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakAnesthesiologyAngiotensin-converting enzymeRenin–angiotensin systemReceptorEnzymePharmacologyInternal medicineVirologyAnesthesiaBlood pressureBiochemistryDiseaseBiologyInfectious disease (medical specialty)
- Has abstract in OpenAlex
- yes