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Record W3010850328 · doi:10.1101/2020.03.16.993667

The utility of a metagenomics approach for marine biomonitoring

2020· preprint· en· W3010850328 on OpenAlexaffabout
Gregory A. C. Singer, Shahrokh Shekarriz, Avery McCarthy, Nicole Fahner, Mehrdad Hajibabaei

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2020
Typepreprint
Languageen
FieldEnvironmental Science
TopicEnvironmental DNA in Biodiversity Studies
Canadian institutionsUniversity of Guelph
Fundersnot available
KeywordsMetagenomicsEnvironmental DNAShotgun sequencingBiodiversityBiologyComputational biologyEcosystemDNA sequencingFunction (biology)BiobankEcologyEvolutionary biologyBioinformaticsGeneGenetics

Abstract

fetched live from OpenAlex

1 Abstract The isolation and analysis of environmental DNA (eDNA) for ecosystem assessment and monitoring has become increasingly popular. A majority of studies have taken a metabarcoding approach—that is, amplifying and sequencing one or more gene targets of interest. Shotgun sequencing of eDNA—also called metagenomics—while popular in microbial community analysis has not seen much adoption for the analysis of other groups of organisms. Especially in light of the existence of extremely high-capacity DNA sequencers, we decided to test the performance of a shotgun approach side-by-side with a metabarcoding approach on marine water samples obtained from offshore Newfoundland. We found that metabarcoding remains the most efficient technique, but that metagenomics also has significant power to reveal biodiversity patterns, and in fact can be treated as an independent confirmation of ecological gradients. Moreover, we show that metagenomics can also be used to infer factors related to ecosystem health and function.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.239
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.004
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.026
GPT teacher head0.213
Teacher spread0.187 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations18
Published2020
Admission routes2
Has abstractyes

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