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Record W3011494106 · doi:10.1212/wnl.0000000000009293

Clinical and radiologic features of pediatric opioid use‐associated neurotoxicity with cerebellar edema (POUNCE) syndrome

2020· article· en· W3011494106 on OpenAlexaff
David Kim, Asuri N. Prasad

Bibliographic record

VenueNeurology · 2020
Typearticle
Languageen
FieldMedicine
TopicPharmacological Effects and Toxicity Studies
Canadian institutionsWestern University
Fundersnot available
KeywordsMedicineAnesthesiapCO2Morphine(+)-NaloxoneMorningAcetaminophenOpioidInternal medicine

Abstract

fetched live from OpenAlex

A 20-month-old boy weighing 15 kg underwent a successful surgery for hypospadias under general anesthesia. Before discharge, he was given a 2 mg dose of oral morphine. His parents reportedly administered a 3 mg dose of oral morphine at home 2 hours later. Three hours later, he appeared drowsy and was put to bed. The next morning, approximately 14 hours later, he was not arousable and the ambulance was called. His oxygen saturation was at 94%, blood pressure at 90/60, and had decreased level of consciousness with poor respiratory effort. His blood venous gas showed pH = 6.91, PCO2 = 115 mm Hg, PO2 = 21 mm Hg, and bicarbonate of 22 mmol/L. He had pinpoint pupils and abnormal dystonic posturing. He was given naloxone 0.15 mg twice, 1 hour apart, with no effect, and he was then intubated.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.018
Threshold uncertainty score0.544

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.046
GPT teacher head0.308
Teacher spread0.261 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations22
Published2020
Admission routes1
Has abstractyes

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