Interactions between Band 3 Anion Exchanger and Lipid Nanodomains in Ternary Lipid Bilayers: Atomistic Simulations
Bibliographic record
Abstract
Band 3 is an anion exchanger for chloride/bicarbonate in the plasma membrane of erythrocytes. The function of Band 3 may be influenced by the interactions between Band 3 and lipids or lipid domains in the plasma membrane. In this work, using atomistic molecular dynamics simulation, we investigate the interactions between Band 3 and nanosized lipid domains in ternary lipid bilayers composed of saturated lipids, unsaturated lipids, and cholesterol. The simulations show asymmetric interactions between Band 3 and lipid nanodomains in the two leaflets of a neutral lipid bilayer with lower cholesterol concentration. With an increase in cholesterol concentration in the bilayer, cholesterol affects the interactions between Band 3 and lipid domains by deforming the structure of the protein. Additionally, the anionic lipids, which prefer to bind to some specific sites of Band 3, also affect the interactions between Band 3 and lipid domains. This work provides some new insight into understanding the distribution of Band 3 in the plasma membrane of erythrocytes as well as its anion exchange function.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".